Detailed view for Smp_000810.1

Basic information

TDR Targets ID: 289932
Schistosoma mansoni, similar to TatD DNase domain containing 1
Source Database / ID:  GeneDB

pI: 6.0409 | Length (AA): 300 | MW (Da): 34222 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01026   TatD related DNase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016888   endodeoxyribonuclease activity, producing 5'-phosphomonoesters  
GO:0016788   hydrolase activity, acting on ester bonds  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 296 2xio (A) 4 293 44.00 0 1 1.58653 -1.18
2 299 3rcm (A) 1 265 31.00 0.000026 1 1.29953 -0.41
3 297 1j6o (A) 0 251 34.00 0 1 1.30933 -0.81
3 296 3e2v (A) 37 416 42.00 0 1 1.412 -1.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126665)

Species Accession Gene Product
Arabidopsis thaliana AT3G52390   TatD related DNase
Babesia bovis BBOV_II007740   hydrolase, TatD family protein
Brugia malayi Bm1_12370   hydrolase, TatD family protein
Candida albicans CaO19.10075   similar to S. cerevisiae YBL055C
Candida albicans CaO19.2541   similar to S. cerevisiae YBL055C
Caenorhabditis elegans CELE_Y24F12A.1   Protein Y24F12A.1
Caenorhabditis elegans CELE_CD4.2   Protein CRN-2
Caenorhabditis elegans CELE_B0432.8   Protein B0432.8
Caenorhabditis elegans CELE_Y37H2A.1   Protein Y37H2A.1, isoform B
Cryptosporidium hominis Chro.60037   CG3358-PB
Cryptosporidium parvum cgd6_250   hypothetical protein
Chlamydia trachomatis CT_594   PHP superfamily hydrolase
Dictyostelium discoideum DDB_G0278649   hypothetical protein
Dictyostelium discoideum DDB_G0269630   TatD-related deoxyribonuclease
Dictyostelium discoideum DDB_G0282531   tatD-related DNAse
Drosophila melanogaster Dmel_CG3358   CG3358 gene product from transcript CG3358-RF
Drosophila melanogaster Dmel_CG3308   CG3308 gene product from transcript CG3308-RA
Escherichia coli b4378   putative DNase
Escherichia coli b1100   putative DNase
Escherichia coli b4483   quality control of Tat-exported FeS proteins
Echinococcus granulosus EgrG_001041600   deoxyribonuclease TATDN1
Entamoeba histolytica EHI_050300   hydrolase TatD family protein
Entamoeba histolytica EHI_119490   hydrolase TatD family protein
Echinococcus multilocularis EmuJ_001041600   deoxyribonuclease TATDN1
Giardia lamblia GL50803_95789   Deoxyribonuclease, TatD family
Homo sapiens ENSG00000203705   TatD DNase domain containing 3
Homo sapiens ENSG00000157014   TatD DNase domain containing 2
Homo sapiens ENSG00000147687   TatD DNase domain containing 1
Leishmania braziliensis LbrM.11.1030   tatD related deoxyribonuclease, putative
Leishmania donovani LdBPK_111270.1   tatD related deoxyribonuclease, putative
Leishmania infantum LinJ.11.1270   tatD related deoxyribonuclease, putative
Leishmania major LmjF.11.1280   tatD related deoxyribonuclease, putative
Leishmania mexicana LmxM.11.1280   tatD related deoxyribonuclease, putative
Loa Loa (eye worm) LOAG_07803   hypothetical protein
Loa Loa (eye worm) LOAG_13580   hydrolase
Mycobacterium leprae ML0239   Probable deoxyribonuclease TatD
Mus musculus ENSMUSG00000026632   TatD DNase domain containing 3
Mus musculus ENSMUSG00000050891   TatD DNase domain containing 1
Mus musculus ENSMUSG00000056952   TatD DNase domain containing 2
Mycobacterium tuberculosis Rv1008   Probable deoxyribonuclease TatD (YJJV protein)
Mycobacterium ulcerans MUL_4653   deoxyribonuclease TatD
Neospora caninum NCLIV_007610   GF17261, related
Oryza sativa 9270278   Os08g0165800
Oryza sativa 4342437   Os07g0158200
Plasmodium berghei PBANKA_0201800   TatD-like deoxyribonuclease
Plasmodium falciparum PF3D7_0112000   TatD-like deoxyribonuclease
Plasmodium knowlesi PKNH_0201600   TatD-like deoxyribonuclease, putative
Plasmodium yoelii PY01446   hydrolase, TatD family
Saccharomyces cerevisiae YBL055C   3'-5'-exodeoxyribonuclease
Schistosoma japonicum Sjp_0205520   ko:K03424 Mg-dependent DNase, putative
Schistosoma mansoni Smp_147810   tatd dnase-related
Schistosoma mansoni Smp_000810.2   tatd dnase-related
Schistosoma mansoni Smp_000810.1   similar to TatD DNase domain containing 1
Schmidtea mediterranea mk4.011965.00   Putative deoxyribonuclease TATDN1
Trypanosoma brucei gambiense Tbg972.11.6850   tatD related deoxyribonuclease, putative
Trypanosoma brucei Tb11.v5.0746   tatD related deoxyribonuclease, putative
Trypanosoma congolense TcIL3000.11.6620   tatD related deoxyribonuclease, putative
Trypanosoma cruzi TcCLB.504149.40   tatD related deoxyribonuclease, putative
Toxoplasma gondii TGME49_253070   hydrolase, TatD family protein
Treponema pallidum TP0979   hypothetical protein
Treponema pallidum TP0994   hypothetical protein
Theileria parva TP02_0686   hypothetical protein, conserved
Trichomonas vaginalis TVAG_481040   conserved hypothetical protein
Trichomonas vaginalis TVAG_230160   conserved hypothetical protein
Wolbachia endosymbiont of Brugia malayi Wbm0245   Mg-dependent Dnase, TadD

Essentiality

Smp_000810.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.3920 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.3920 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.3920 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.3920 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b1100 Escherichia coli non-essential goodall
b4483 Escherichia coli non-essential goodall
b4378 Escherichia coli non-essential goodall
TGME49_253070 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_000810.1 (Schistosoma mansoni), similar to TatD DNase domain containing 1
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