pI: 9.2057 |
Length (AA): 276 |
MW (Da): 31620 |
Paralog Number:
7
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
109 | 255 | 4uos (A) | 2 | 154 | 10.00 | 0.0068 | 0.03 | 0.688109 | -1.2 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127248)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G51410 | LUC7 N_terminus domain-containing protein |
Babesia bovis | BBOV_II005650 | conserved hypothetical protein |
Brugia malayi | Bm1_53165 | Hypothetical 37.0 kDa protein B0495.8 in chromosome II, putative |
Brugia malayi | Bm1_55660 | putative salt tolerance protein |
Candida albicans | CaO19.3116 | interacts with cap-binding complex |
Candida albicans | CaO19.10628 | interacts with cap-binding complex |
Caenorhabditis elegans | CELE_C50D2.8 | Protein C50D2.8 |
Caenorhabditis elegans | CELE_B0495.8 | Protein B0495.8, isoform B |
Cryptosporidium hominis | Chro.60294 | hypothetical protein |
Cryptosporidium parvum | cgd6_2550 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0278799 | Luc7 family protein |
Drosophila melanogaster | Dmel_CG7564 | CG7564 gene product from transcript CG7564-RD |
Echinococcus granulosus | EgrG_000201900 | LUC7 |
Echinococcus granulosus | EgrG_000582100 | LUC7 |
Echinococcus multilocularis | EmuJ_000582100 | LUC7 |
Echinococcus multilocularis | EmuJ_000201900 | LUC7 |
Homo sapiens | 100996928 | C7orf55-LUC7L2 readthrough |
Homo sapiens | ENSG00000146963 | LUC7-like 2 (S. cerevisiae) |
Homo sapiens | ENSG00000007392 | LUC7-like (S. cerevisiae) |
Homo sapiens | ENSG00000108848 | LUC7-like 3 (S. cerevisiae) |
Loa Loa (eye worm) | LOAG_00023 | hypothetical protein |
Loa Loa (eye worm) | LOAG_07603 | hypothetical protein |
Mus musculus | ENSMUSG00000024188 | Luc7 homolog (S. cerevisiae)-like |
Mus musculus | ENSMUSG00000020863 | LUC7-like 3 (S. cerevisiae) |
Mus musculus | ENSMUSG00000029823 | LUC7-like 2 (S. cerevisiae) |
Neospora caninum | NCLIV_024960 | hypothetical protein |
Neospora caninum | NCLIV_011870 | hypothetical protein |
Oryza sativa | 4343144 | Os07g0456400 |
Onchocerca volvulus | OVOC10365 |
|
Plasmodium berghei | PBANKA_1316400 | U1 snRNA associated protein, putative |
Plasmodium falciparum | PF3D7_1452700 | U1 snRNA associated protein, putative |
Plasmodium knowlesi | PKNH_1229400 | U1 snRNA associated protein, putative |
Plasmodium vivax | PVX_117845 | hypothetical protein, conserved |
Plasmodium yoelii | PY04945 | cisplatin resistance-associated overexpressed protein-related |
Saccharomyces cerevisiae | YDL087C | Luc7p |
Schistosoma japonicum | Sjp_0103100 | Cisplatin resistance-associated overexpressed protein, putative |
Schistosoma japonicum | Sjp_0034440 | Putative RNA-binding protein Luc7-like 2, putative |
Schistosoma japonicum | Sjp_0217690 | expressed protein |
Schistosoma mansoni | Smp_031920.5 | hypothetical protein |
Schistosoma mansoni | Smp_031920.1 | hypothetical protein |
Schistosoma mansoni | Smp_031920.7 | hypothetical protein |
Schistosoma mansoni | Smp_031920.3 | hypothetical protein |
Schistosoma mansoni | Smp_015850.3 | hypothetical protein |
Schistosoma mansoni | Smp_015850.2 | hypothetical protein |
Schistosoma mansoni | Smp_031920.2 | hypothetical protein |
Schistosoma mansoni | Smp_031920.4 | hypothetical protein |
Schmidtea mediterranea | mk4.001787.02 | |
Schmidtea mediterranea | mk4.001117.00 | |
Schmidtea mediterranea | mk4.000600.04 | |
Schmidtea mediterranea | mk4.025822.00 | |
Schmidtea mediterranea | mk4.006449.00 | |
Schmidtea mediterranea | mk4.010553.02 | |
Toxoplasma gondii | TGME49_262960 | U1 snRNP-associated protein Usp106, putative |
Toxoplasma gondii | TGME49_210980 | alternative splicing type 3 and, putative |
Theileria parva | TP02_0516 | hypothetical protein |
Trichomonas vaginalis | TVAG_030410 | exm2 protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_B0495.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
YDL087C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_262960 | Toxoplasma gondii | Probably essential | sidik |
TGME49_210980 | Toxoplasma gondii | Probably essential | sidik |
TGME49_262960 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_210980 | Toxoplasma gondii | Probably non-essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.