Detailed view for Smp_163780

Basic information

TDR Targets ID: 290807
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 6.0433 | Length (AA): 522 | MW (Da): 57844 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 176 5nqv (A) 8 179 17.00 0.00000000052 0.19 0.524165 -0.34
1 199 5ja5 (A) 8 204 21.00 0 0.99 0.555726 -0.08
1 176 5en8 (A) 11 177 20.00 0 0.72 0.514665 -0.18
205 505 5nuv (A) 311 604 24.00 0.054 1 0.846128 -0.49
217 336 5m89 (A) 321 435 33.00 0.015 1 0.621385 -0.31
225 291 5k19 (A) 228 289 42.00 0.0036 0.76 0.316852 0.78
448 505 4ci8 (A) 755 812 17.00 0 0.12 0.344611 -0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129140)

Species Accession Gene Product
Arabidopsis thaliana AT5G08560   WD40 domain-containing protein
Arabidopsis thaliana AT5G43920   transducin/WD40 domain-containing protein
Babesia bovis BBOV_II003290   WD domain, G-beta repeat containing protein
Brugia malayi Bm1_40855   WD-repeat protein 26
Caenorhabditis elegans CELE_Y39H10A.6   Protein Y39H10A.6
Dictyostelium discoideum DDB_G0288313   hypothetical protein
Drosophila melanogaster Dmel_CG7611   CG7611 gene product from transcript CG7611-RI
Echinococcus granulosus EgrG_000465000   WD repeat containing protein 26
Echinococcus multilocularis EmuJ_000465000   WD repeat containing protein 26
Homo sapiens ENSG00000162923   WD repeat domain 26
Loa Loa (eye worm) LOAG_03332   WD-repeat protein 26
Mus musculus ENSMUSG00000038733   WD repeat domain 26
Neospora caninum NCLIV_036690   hypothetical protein
Oryza sativa 4348836   Os10g0465000
Oryza sativa 9266581   Os02g0294600
Onchocerca volvulus OVOC5355  
Plasmodium berghei PBANKA_1233400   WD repeat-containing protein 26, putative
Plasmodium falciparum PF3D7_0518600   WD repeat-containing protein 26, putative
Plasmodium knowlesi PKNH_1014600   WD repeat-containing protein 26, putative
Plasmodium vivax PVX_080315   hypothetical protein, conserved
Plasmodium yoelii PY02029   hypothetical protein
Schistosoma japonicum Sjp_0051780   WD repeat-containing protein 26, putative
Schistosoma mansoni Smp_163780   hypothetical protein
Schmidtea mediterranea mk4.000003.13   Putative wd-repeat protein
Schmidtea mediterranea mk4.000003.10  
Toxoplasma gondii TGME49_269900   WD domain, G-beta repeat-containing protein
Theileria parva TP04_0264   hypothetical protein, conserved

Essentiality

Smp_163780 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y39H10A.6 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_1233400 Plasmodium berghei Dispensable plasmo
TGME49_269900 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_163780 (Schistosoma mansoni), hypothetical protein
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