Detailed view for Smp_135570

Basic information

TDR Targets ID: 290984
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 6.8196 | Length (AA): 353 | MW (Da): 40011 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00022   Actin

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  
GO:0005515   protein binding  
GO:0006338   chromatin remodeling  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 353 4b1y (B) 4 313 24.00 0.00012 1 1.07297 0.36
6 65 3kvg (A) 212 263 40.00 0.28 0.17 0.276872 1.53
6 353 5i9e (D) 8 313 34.00 0 1 1.10074 0.48
6 353 1d4x (A) 8 313 30.00 0 1 1.17674 0.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129661)

Species Accession Gene Product
Arabidopsis thaliana AT3G33520   actin-related protein 6
Brugia malayi Bm1_43455   Actin family protein
Candida albicans CaO19.12369   Actin-related protein involved in protein vacuolar targeting
Candida albicans CaO19.4904   Actin-related protein involved in protein vacuolar targeting
Caenorhabditis elegans CELE_C08B11.6   Protein ARP-6
Cryptosporidium hominis Chro.50252   actin-like protein
Cryptosporidium parvum cgd5_1320   actin-like protein, putative
Dictyostelium discoideum DDB_G0287007   actin related protein 6
Drosophila melanogaster Dmel_CG11678   Actin-related protein 6
Echinococcus granulosus EgrG_000764100   Actin protein 6
Echinococcus multilocularis EmuJ_000764100   Actin protein 6
Homo sapiens ENSG00000075089   ARP6 actin-related protein 6 homolog (yeast)
Loa Loa (eye worm) LOAG_01190   actin family protein
Mus musculus ENSMUSG00000019948   ARP6 actin-related protein 6
Oryza sativa 4326270   Os01g0269900
Saccharomyces cerevisiae YLR085C   Arp6p
Schistosoma japonicum Sjp_0202160   Actin-related protein 6, putative
Schistosoma mansoni Smp_135570   hypothetical protein
Schmidtea mediterranea mk4.000456.10   Actin-like protein

Essentiality

Smp_135570 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C08B11.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_C08B11.6 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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