Detailed view for PF3D7_1460800

Basic information

TDR Targets ID: 2910
Plasmodium falciparum, snRNA-activating protein complex subunit 3, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.8297 | Length (AA): 635 | MW (Da): 75928 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12251   snRNA-activating protein of 50kDa MW C terminal

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
46 277 3cml (A) 1286 1565 19.00 0.64 0.34 0.432354 0.28
182 360 4uos (A) 2 184 13.00 0.0034 0.03 0.42689 -0.98
47 174 2ycu (A) 856 979 10.00 0 0.01 0.0920362 -0.73

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Female Gametocyte. Otto TD Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Oocyst, Ring, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 8 hs. Otto TD
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_129228)

Species Accession Gene Product
Arabidopsis thaliana AT1G28560   protein shoot redifferentiation defective 2
Babesia bovis BBOV_III010690   hypothetical protein
Brugia malayi Bm1_46635   hypothetical protein
Caenorhabditis elegans CELE_B0273.3   Protein B0273.3
Caenorhabditis elegans CELE_Y48G1BM.1   Protein Y48G1BM.1
Caenorhabditis elegans CELE_T02C12.2   Protein T02C12.2
Cryptosporidium hominis Chro.70130   hypothetical protein
Cryptosporidium parvum cgd7_1050   hypothetical protein
Dictyostelium discoideum DDB_G0274687   hypothetical protein
Drosophila melanogaster Dmel_CG42515   PSEA-binding protein 49kD
Drosophila melanogaster Dmel_CG42516   CG42516 gene product from transcript CG42516-RB
Echinococcus granulosus EgrG_000128600   expressed conserved protein
Echinococcus granulosus EgrG_000128500   snRNA activating protein complex subunit 3
Entamoeba histolytica EHI_197110   snRNA activating protein complex subunit, putative
Echinococcus multilocularis EmuJ_000128500   snRNA activating protein complex subunit 3
Echinococcus multilocularis EmuJ_000128600   expressed conserved protein
Homo sapiens 6619   small nuclear RNA activating complex, polypeptide 3, 50kDa
Leishmania braziliensis LbrM.34.4640   small nuclear RNA gene activation protein (SNAP) 50, putative
Leishmania donovani LdBPK_354730.1   small nuclear RNA gene activation protein (SNAP) 50, putative
Leishmania infantum LinJ.35.4730   small nuclear RNA gene activation protein (SNAP) 50, putative
Leishmania major LmjF.35.4660   small nuclear RNA gene activation protein (SNAP) 50, putative
Leishmania mexicana LmxM.34.4660   small nuclear RNA gene activation protein (SNAP) 50, putative
Loa Loa (eye worm) LOAG_10462   hypothetical protein
Mus musculus ENSMUSG00000028483   small nuclear RNA activating complex, polypeptide 3
Oryza sativa 4324317   Os01g0912600
Plasmodium berghei PBANKA_1324500   snRNA-activating protein complex subunit 3, putative
Plasmodium falciparum PF3D7_1460800   snRNA-activating protein complex subunit 3, putative
Plasmodium knowlesi PKNH_1220900   snRNA-activating protein complex subunit 3, putative
Plasmodium vivax PVX_117415   snRNA-activating protein complex subunit 3, putative
Plasmodium yoelii PY05165   hypothetical protein
Schistosoma japonicum Sjp_0214600   snRNA-activating protein complex subunit 3, putative
Schistosoma mansoni Smp_092780.1   hypothetical protein
Schistosoma mansoni Smp_092780.2   hypothetical protein
Schmidtea mediterranea mk4.010426.00   snRNA-activating protein complex subunit 3
Trypanosoma brucei gambiense Tbg972.9.5750   small nuclear RNA gene activation protein (SNAP) 50, putative
Trypanosoma brucei Tb927.9.9970   Small nuclear RNA gene activation protein (SNAP) 50
Trypanosoma congolense TcIL3000_9_3640   small nuclear RNA gene activation protein 50 (EMBL:AJ581666)
Trypanosoma cruzi TcCLB.510731.50   small nuclear RNA gene activation protein (SNAP) 50, putative
Trypanosoma cruzi TcCLB.506887.60   small nuclear RNA gene activation protein (SNAP) 50, putative
Theileria parva TP02_0077   hypothetical protein

Essentiality

PF3D7_1460800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.1510 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.1510 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.1510 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.1510 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T02C12.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_T02C12.2 Caenorhabditis elegans larval arrest wormbase
CELE_T02C12.2 Caenorhabditis elegans larval lethal wormbase
CELE_T02C12.2 Caenorhabditis elegans slow growth wormbase
CELE_T02C12.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1460800 (Plasmodium falciparum), snRNA-activating protein complex subunit 3, putative
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