Detailed view for Smp_141970

Basic information

TDR Targets ID: 291076
Schistosoma mansoni, deoxyribose-phosphate aldolase
Source Database / ID:  GeneDB

pI: 5.0295 | Length (AA): 316 | MW (Da): 34622 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01791   DeoC/LacD family aldolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0004139   deoxyribose-phosphate aldolase activity  
GO:0003824   catalytic activity  
GO:0016829   lyase activity  
GO:0008152   metabolic process  
GO:0009264   deoxyribonucleotide catabolic process  

Metabolic Pathways

Pentose phosphate pathway (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
25 295 3r12 (A) 8 240 30.00 0 1 1.11199 -0.25
38 300 1p1x (A) 2 250 42.00 0 1 1.36668 -0.85
38 299 5c5y (A) 2 246 40.00 0 1 1.35291 -1.13

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127821)

Species Accession Gene Product
Brugia malayi Bm1_16595   deoxyribose-phosphate aldolase
Caenorhabditis elegans CELE_F09E5.3   Protein F09E5.3
Drosophila melanogaster Dmel_CG8525   CG8525 gene product from transcript CG8525-RA
Escherichia coli b4381   2-deoxyribose-5-phosphate aldolase, NAD(P)-linked
Echinococcus granulosus EgrG_000162000   deoxyribose phosphate aldolase
Entamoeba histolytica EHI_121800   deoxyribose-phosphate aldolase, putative
Echinococcus multilocularis EmuJ_000162000   deoxyribose phosphate aldolase
Giardia lamblia GL50803_15127   Deoxyribose-phosphate aldolase lateral transfer candidate
Homo sapiens ENSG00000023697   deoxyribose-phosphate aldolase (putative)
Leishmania braziliensis LbrM.06.1050   deoxyribose-phosphate aldolase, putative
Leishmania donovani LdBPK_061110.1   deoxyribose-phosphate aldolase, putative
Leishmania infantum LinJ.06.1110   deoxyribose-phosphate aldolase, putative
Leishmania major LmjF.06.1070   deoxyribose-phosphate aldolase, putative
Leishmania mexicana LmxM.06.1070   deoxyribose-phosphate aldolase, putative
Loa Loa (eye worm) LOAG_10432   hypothetical protein
Mycobacterium leprae ML2451c   PROBABLE DEOXYRIBOSE-PHOSPHATE ALDOLASE DEOC (PHOSPHODEOXYRIBOALDOLASE) (DEOXYRIBOALDOLASE)
Mus musculus ENSMUSG00000030225   2-deoxyribose-5-phosphate aldolase homolog (C. elegans)
Mycobacterium tuberculosis Rv0478   Probable deoxyribose-phosphate aldolase DeoC (phosphodeoxyriboaldolase) (deoxyriboaldolase)
Mycobacterium ulcerans MUL_4546   deoxyribose-phosphate aldolase
Neospora caninum NCLIV_036120   deoxyribose-phosphate aldolase, putative
Plasmodium berghei PBANKA_0505800   deoxyribose-phosphate aldolase, putative
Plasmodium falciparum PF3D7_1021600   deoxyribose-phosphate aldolase, putative
Plasmodium knowlesi PKNH_0605900   deoxyribose-phosphate aldolase, putative
Plasmodium vivax PVX_001945   deoxyribose-phosphate aldolase, putative
Plasmodium yoelii PY02252   deoxyribose-phosphate aldolase
Schistosoma japonicum Sjp_0039050   ko:K01619 deoxyribose-phosphate aldolase [EC4.1.2.4], putative
Schistosoma japonicum Sjp_0107210   Putative deoxyribose-phosphate aldolase, putative
Schistosoma mansoni Smp_141970   deoxyribose-phosphate aldolase
Schmidtea mediterranea mk4.021160.00  
Schmidtea mediterranea mk4.011344.00  
Trypanosoma brucei gambiense Tbg972.7.6600   deoxyribose-phosphate aldolase, putative
Trypanosoma brucei Tb927.7.5680   deoxyribose-phosphate aldolase, putative
Trypanosoma congolense TcIL3000_7_4670   deoxyribose-phosphate aldolase, putative
Trypanosoma cruzi TcCLB.510303.50   deoxyribose-phosphate aldolase, putative
Trypanosoma cruzi TcCLB.507559.80   deoxyribose-phosphate aldolase, putative
Toxoplasma gondii TGME49_270650   deoxyribose-phosphate aldolase
Treponema pallidum TP0264   deoxyribose-phosphate aldolase (deoC)
Trichomonas vaginalis TVAG_468210   deoxyribose-phosphate aldolase, putative
Trichomonas vaginalis TVAG_393280   deoxyribose-phosphate aldolase, putative

Essentiality

Smp_141970 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.5680 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.5680 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.5680 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.7.5680 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b4381 Escherichia coli non-essential goodall
TGME49_270650 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_141970 (Schistosoma mansoni), deoxyribose-phosphate aldolase
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