Detailed view for Smp_161480

Basic information

TDR Targets ID: 291145
Schistosoma mansoni, eukaryotic translation initiation factor 3 subunit (eif-3)
Source Database / ID:  GeneDB

pI: 6.7313 | Length (AA): 1006 | MW (Da): 114571 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12807   Translation initiation factor eIF3 subunit 135
PF13236   Clustered mitochondria

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
533 674 3nf1 (A) 209 350 21.00 0 1 0.522053 -0.96
900 965 2avp (A) 1 66 12.00 0.57 0.02 0.268406 -1.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129358)

Species Accession Gene Product
Arabidopsis thaliana AT3G52140   tetratricopeptide repeat (TPR)-containing protein
Brugia malayi Bm1_28595   eukaryotic translation initiation factor 3 subunit, putative
Brugia malayi Bm1_04245   Putative eukaryotic translation initiation factor 3 subunit (eIF-3)
Candida albicans CaO19.7712   similar toS. cerevisiae CLU1 (YMR012W) translation initiation factor eIF3, p135 subunit
Candida albicans CaO19.51   similar toS. cerevisiae CLU1 (YMR012W) translation initiation factor eIF3, p135 subunit
Caenorhabditis elegans CELE_F55H2.6   Protein CLU-1
Dictyostelium discoideum DDB_G0292806   150 kDa protein
Drosophila melanogaster Dmel_CG8443   clueless
Echinococcus granulosus EgrG_000129400   eukaryotic translation initiation
Echinococcus multilocularis EmuJ_000129400   eukaryotic translation initiation
Homo sapiens ENSG00000132361   clustered mitochondria (cluA/CLU1) homolog
Loa Loa (eye worm) LOAG_14676   hypothetical protein
Loa Loa (eye worm) LOAG_08845   hypothetical protein
Loa Loa (eye worm) LOAG_08846   hypothetical protein
Mus musculus ENSMUSG00000020741   clustered mitochondria (cluA/CLU1) homolog
Neospora caninum NCLIV_066510   Protein KIAA0664, related
Oryza sativa 4330529   Os02g0717400
Saccharomyces cerevisiae YMR012W   Clu1p
Schistosoma japonicum Sjp_0127940   Putative eukaryotic translation initiation factor 3 subunit, putative
Schistosoma japonicum Sjp_0103770   ko:K03255 translation initiation factor eIF-3 subunit P135, putative
Schistosoma mansoni Smp_161480   eukaryotic translation initiation factor 3 subunit (eif-3)
Schmidtea mediterranea mk4.018777.00   Clustered mitochondria protein homolog
Schmidtea mediterranea mk4.017599.00   Clustered mitochondria protein homolog
Schmidtea mediterranea mk4.020811.00   Clustered mitochondria protein homolog
Toxoplasma gondii TGME49_251410   tetratricopeptide repeat-containing protein
Trichomonas vaginalis TVAG_221470   conserved hypothetical protein

Essentiality

Smp_161480 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F55H2.6 Caenorhabditis elegans embryonic lethal wormbase
TGME49_251410 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_161480 (Schistosoma mansoni), eukaryotic translation initiation factor 3 subunit (eif-3)
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