Detailed view for Smp_170700

Basic information

TDR Targets ID: 291325
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 5.2562 | Length (AA): 1086 | MW (Da): 125443 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
127 506 4ci8 (A) 216 583 24.00 0.0000000071 1 0.451008 0.72
880 913 5j73 (A) 3 36 44.00 0.91 0.15 0.760408 -2.81

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130581)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG34124   CG34124 gene product from transcript CG34124-RA
Echinococcus granulosus EgrG_000880900   WD repeat containing protein 52
Echinococcus multilocularis EmuJ_000880900   WD repeat containing protein 52
Giardia lamblia GL50803_42000   Coiled-coil protein
Homo sapiens ENSG00000206530   cilia and flagella associated protein 44
Leishmania braziliensis LbrM.14.1620   hypothetical protein, conserved
Leishmania donovani LdBPK_141530.1   hypothetical protein, conserved
Leishmania infantum LinJ.14.1530   hypothetical protein, conserved
Leishmania major LmjF.14.1430   hypothetical protein, conserved
Leishmania mexicana LmxM.14.1430   hypothetical protein, conserved
Mus musculus ENSMUSG00000071550   cilia and flagella associated protein 44
Neospora caninum NCLIV_062990   hypothetical protein
Neospora caninum NCLIV_063000   Coiled-coil protein, related
Schistosoma japonicum Sjp_0112620   Conserved hypothetical protein
Schistosoma japonicum Sjp_0004160   Conserved hypothetical protein
Schistosoma japonicum Sjp_0114340   IPR011046,WD40-like,domain-containing
Schistosoma japonicum Sjp_0004150   Conserved hypothetical protein
Schistosoma mansoni Smp_170710   Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2)
Schistosoma mansoni Smp_170700   hypothetical protein
Schmidtea mediterranea mk4.005538.02   Putative wd-repeat protein
Trypanosoma brucei gambiense Tbg972.7.3940   hypothetical protein, conserved
Trypanosoma brucei Tb927.7.3560   Component of motile flagella 7
Trypanosoma congolense TcIL3000_7_2800   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509939.19   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506441.10   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508265.110   hypothetical protein, conserved
Trichomonas vaginalis TVAG_423210   WD-repeat protein, putative

Essentiality

Smp_170700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.3560 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.3560 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.3560 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.3560 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_170700 (Schistosoma mansoni), hypothetical protein
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