Detailed view for Smp_133910

Basic information

TDR Targets ID: 291588
Schistosoma mansoni, huntingtin interacting protein-related
Source Database / ID:  GeneDB

pI: 6.0602 | Length (AA): 1575 | MW (Da): 176912 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00856   SET domain
PF09243   Mitochondrial small ribosomal subunit Rsm22

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  
GO:0018024   histone-lysine N-methyltransferase activity  
GO:0008168   methyltransferase activity  
GO:0005515   protein binding  
GO:0006412   translation  

Metabolic Pathways

Lysine degradation (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
378 593 6cen (A) 1078 1285 47.00 0 1 0.599643 0.25
395 597 5jlb (A) 1484 1694 48.00 0 1 0.682389 0.14
464 569 5bjs (B) 808 918 39.00 0.00000000017 1 0.519802 0.05
1275 1409 1xxl (A) 0 122 15.00 0.27 0.18 0.210314 -0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130837)

Species Accession Gene Product
Arabidopsis thaliana AT1G64600   copper ion binding / methyltransferase
Babesia bovis BBOV_IV005190   hypothetical protein
Brugia malayi Bm1_51900   false p73 target protein
Caenorhabditis elegans CELE_F32A7.4   Protein F32A7.4
Dictyostelium discoideum DDB_G0292286   hypothetical protein
Drosophila melanogaster Dmel_CG13126   CG13126 gene product from transcript CG13126-RB
Echinococcus granulosus EgrG_000675700   huntingtin interacting protein
Echinococcus multilocularis EmuJ_000675700   huntingtin interacting protein
Homo sapiens ENSG00000165792   methyltransferase like 17
Loa Loa (eye worm) LOAG_07689   hypothetical protein
Loa Loa (eye worm) LOAG_06597   hypothetical protein
Mus musculus ENSMUSG00000004561   methyltransferase like 17
Neospora caninum NCLIV_054760   hypothetical protein, conserved
Oryza sativa 4342969   Os07g0297300
Plasmodium berghei PBANKA_0511300   mitochondrial ribosomal protein S22 precursor, putative
Plasmodium falciparum PF3D7_1027200   mitochondrial ribosomal protein S22 precursor, putative
Plasmodium knowlesi PKNH_0611600   mitochondrial ribosomal protein S22 precursor, putative
Plasmodium vivax PVX_111360   hypothetical protein, conserved
Plasmodium yoelii PY03833   Drosophila melanogaster RE01590p, putative
Schistosoma japonicum Sjp_0301760   Protein RSM22 homolog, mitochondrial precursor, putative
Schistosoma mansoni Smp_133910   huntingtin interacting protein-related
Schmidtea mediterranea mk4.001186.01  
Toxoplasma gondii TGME49_310710   small ribosomal subunit Rsm22 protein
Theileria parva TP01_0223   hypothetical protein, conserved

Essentiality

Smp_133910 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F32A7.4 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_0511300 Plasmodium berghei Essential plasmo
TGME49_310710 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_133910 (Schistosoma mansoni), huntingtin interacting protein-related
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