Detailed view for Smp_062530

Basic information

TDR Targets ID: 291603
Schistosoma mansoni, suppressor of variegation 4-20-related
Source Database / ID:  GeneDB

pI: 9.3212 | Length (AA): 613 | MW (Da): 69350 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00856   SET domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0034773   GO:histone H4-K20 trimethylation  

GO:0042799   histone lysine N-methyltransferase activity (H4-K20 specific)  
GO:0005515   protein binding  

Metabolic Pathways

Lysine degradation (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
28 266 4au7 (A) 5 242 43.00 0 1 0.910086 -0.28
29 267 3s8p (A) 72 333 48.00 0 1 0.911986 -0.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130941)

Species Accession Gene Product
Brugia malayi Bm1_06250   SET domain containing protein
Caenorhabditis elegans CELE_C32D5.5   Protein SET-4
Drosophila melanogaster Dmel_CG13363   Histone methyltransferase 4-20
Echinococcus granulosus EgrG_000750400   histone lysine n methyltransferase suv420h1
Echinococcus multilocularis EmuJ_000750400   histone lysine n methyltransferase suv420h1
Homo sapiens ENSG00000133247   suppressor of variegation 4-20 homolog 2 (Drosophila)
Homo sapiens ENSG00000110066   suppressor of variegation 4-20 homolog 1 (Drosophila)
Loa Loa (eye worm) LOAG_03384   SET domain-containing protein
Mus musculus ENSMUSG00000045098   suppressor of variegation 4-20 homolog 1 (Drosophila)
Mus musculus ENSMUSG00000059851   suppressor of variegation 4-20 homolog 2 (Drosophila)
Schistosoma japonicum Sjp_0003700   ko:K05302 histone-lysine N-methyltransferase [EC2.1.1.43], putative
Schistosoma mansoni Smp_062530   suppressor of variegation 4-20-related
Schmidtea mediterranea mk4.001370.04   Histone-lysine N-methyltransferase Suv4-20
Schmidtea mediterranea mk4.001370.03   Histone-lysine N-methyltransferase Suv4-20

Essentiality

Smp_062530 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C32D5.5 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens suppressor of variegation 4-20 homolog 2 (Drosophila) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_062530 (Schistosoma mansoni), suppressor of variegation 4-20-related
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