Detailed view for Smp_172130

Basic information

TDR Targets ID: 291628
Schistosoma mansoni, SUMO ligase
Source Database / ID:  GeneDB

pI: 7.5401 | Length (AA): 1147 | MW (Da): 127180 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02891   MIZ/SP-RING zinc finger
PF14324   PINIT domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0019789   SUMO ligase activity  
GO:0008270   zinc ion binding  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
300 639 4mvt (A) 127 405 41.00 0 1 0.281825 0.61
410 639 4mvt (A) 204 405 49.00 0 1 0.520823 0.39
680 1064 6gw5 (A) 24 433 9.00 0 0.01 0.357058 -0.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128433)

Species Accession Gene Product
Brugia malayi Bm1_48650   MIZ zinc finger family protein
Caenorhabditis elegans CELE_W10D5.3   Protein GEI-17, isoform D
Dictyostelium discoideum DDB_G0274743   MIZ-type zinc finger-containing protein
Drosophila melanogaster Dmel_CG8068   Suppressor of variegation 2-10
Echinococcus granulosus EgrG_000321900   miz zinc finger family protein
Echinococcus granulosus EgrG_000941500   e3 SUMO protein ligase PIAS2
Entamoeba histolytica EHI_098320   SP-RING zinc finger domain containing protein
Echinococcus multilocularis EmuJ_000941500   e3 SUMO protein ligase PIAS2
Homo sapiens ENSG00000131788   protein inhibitor of activated STAT, 3
Homo sapiens ENSG00000078043   protein inhibitor of activated STAT, 2
Homo sapiens 8554   protein inhibitor of activated STAT, 1
Loa Loa (eye worm) LOAG_05528   MIZ zinc finger family protein
Mus musculus ENSMUSG00000032405   protein inhibitor of activated STAT 1
Mus musculus ENSMUSG00000025423   protein inhibitor of activated STAT 2
Mus musculus ENSMUSG00000028101   protein inhibitor of activated STAT 3
Saccharomyces cerevisiae YDR409W   SUMO ligase SIZ1
Schistosoma japonicum Sjp_0095460   expressed protein
Schistosoma japonicum Sjp_0003620   Serine/threonine-protein kinase SNF1-like kinase 2, putative
Schistosoma mansoni Smp_172130   SUMO ligase
Schmidtea mediterranea mk4.004161.01   LD16921p
Schmidtea mediterranea mk4.005339.00   E3 SUMO-protein ligase gei-17
Schmidtea mediterranea mk4.005124.00   LD16921p
Schmidtea mediterranea mk4.000188.12  
Schmidtea mediterranea mk4.009405.01   LD16921p
Trichomonas vaginalis TVAG_414850   sumo ligase, putative

Essentiality

Smp_172130 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_W10D5.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_W10D5.3 Caenorhabditis elegans larval arrest wormbase
CELE_W10D5.3 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_172130 (Schistosoma mansoni), SUMO ligase
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