pI: 7.1565 |
Length (AA): 538 |
MW (Da): 58047 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
19 | 535 | 4b2t (d) | 1024 | 1541 | 70.00 | 0 | 1 | 1.05767 | 2.17 |
19 | 535 | 4b2t (D) | 24 | 541 | 53.00 | 0 | 1 | 1.41367 | 0.67 |
22 | 534 | 4b2t (D) | 27 | 540 | 68.00 | 0 | 1 | 1.65763 | -0.17 |
222 | 377 | 1ass (A) | 1 | 152 | 27.00 | 0 | 1 | 0.704663 | -1.11 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127832)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G18190 | TCP-1/cpn60 chaperonin family protein |
Babesia bovis | BBOV_IV005030 | T-complex protein 1 delta subunit, putative |
Brugia malayi | Bm1_17890 | T-complex protein 1, delta subunit |
Candida albicans | CaO19.10235 | similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol |
Candida albicans | CaO19.2720 | similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol |
Caenorhabditis elegans | CELE_K01C8.10 | Protein CCT-4 |
Cryptosporidium hominis | Chro.50193 | chaperonin containing TCP-1 delta subunit |
Cryptosporidium parvum | cgd5_1880 | conserved probable chaperonin containing TCP-1 delta subunit |
Dictyostelium discoideum | DDB_G0292872 | chaperonin containing TCP1 delta subunit |
Drosophila melanogaster | Dmel_CG5525 | CG5525 gene product from transcript CG5525-RA |
Echinococcus granulosus | EgrG_000909400 | T complex protein 1 subunit delta |
Entamoeba histolytica | EHI_114120 | chaperonin containing TCP-1 delta subunit, putative |
Echinococcus multilocularis | EmuJ_000909400 | T complex protein 1 subunit delta |
Giardia lamblia | GL50803_17482 | TCP-1 chaperonin subunit alpha |
Homo sapiens | ENSG00000115484 | chaperonin containing TCP1, subunit 4 (delta) |
Leishmania braziliensis | LbrM.21.1320 | T-complex protein 1, delta subunit, putative |
Leishmania donovani | LdBPK_211330.1 | T-complex protein 1, delta subunit, putative |
Leishmania infantum | LinJ.21.1330 | T-complex protein 1, delta subunit, putative |
Leishmania major | LmjF.21.1090 | T-complex protein 1, delta subunit, putative |
Leishmania mexicana | LmxM.21.1090 | T-complex protein 1, delta subunit, putative |
Loa Loa (eye worm) | LOAG_08729 | T-complex protein 1 |
Mus musculus | ENSMUSG00000007739 | chaperonin containing Tcp1, subunit 4 (delta) |
Neospora caninum | NCLIV_034530 | TCP-1/cpn60 family chaperonin, putative |
Oryza sativa | 4349108 | Os10g0514600 |
Oryza sativa | 4329211 | Os02g0332200 |
Plasmodium berghei | PBANKA_1134100 | T-complex protein 1 subunit delta, putative |
Plasmodium falciparum | PF3D7_1357800 | T-complex protein 1 subunit delta |
Plasmodium knowlesi | PKNH_1113700 | T-complex protein 1 subunit delta, putative |
Plasmodium vivax | PVX_114865 | T-complex protein 1 subunit delta, putative |
Plasmodium yoelii | PY02937 | chaperonin containing TCP-1 delta subunit |
Saccharomyces cerevisiae | YDL143W | Cct4p |
Schistosoma japonicum | Sjp_0013990 | ko:K09496 T-complex protein 1 subunit delta, putative |
Schistosoma mansoni | Smp_004600 | chaperonin containing t-complex protein 1 delta subunit tcpd |
Schmidtea mediterranea | mk4.000655.03 | T-complex protein 1 subunit delta |
Schmidtea mediterranea | mk4.000655.02 | T-complex protein 1 subunit delta |
Trypanosoma brucei gambiense | Tbg972.10.1340 | T-complex protein 1, delta subunit, putative |
Trypanosoma brucei | Tb927.10.1060 | T-complex protein 1, delta subunit, putative |
Trypanosoma congolense | TcIL3000_10_870 | T-complex protein 1, delta subunit, putative |
Trypanosoma cruzi | TcCLB.509695.200 | T-complex protein 1, delta subunit, putative |
Toxoplasma gondii | TGME49_272910 | T-complex protein 1 delta subunit |
Theileria parva | TP01_0241 | chaperonin 60 kDa, putative |
Trichomonas vaginalis | TVAG_137820 | chaperonin containing t-complex protein 1, eta subunit, tcph, putative |
Trichomonas vaginalis | TVAG_066690 | chaperonin containing t-complex protein 1, epsilon subunit, tcpe, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.1060 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.1060 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.1060 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.1060 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_K01C8.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K01C8.10 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K01C8.10 | Caenorhabditis elegans | slow growth | wormbase |
CELE_K01C8.10 | Caenorhabditis elegans | sterile | wormbase |
YDL143W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1134100 | Plasmodium berghei | Essential | plasmo |
TGME49_272910 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Macaaca fascicularis | T-complex protein 1 subunit beta | 535 aa | 32.8% | 530 aa | Compounds | References |