Detailed view for Smp_054540

Basic information

TDR Targets ID: 292031
Schistosoma mansoni, microtubule-associated protein rp/eb family
Source Database / ID:  GeneDB

pI: 6.246 | Length (AA): 276 | MW (Da): 31332 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00307   Calponin homology (CH) domain
PF03271   EB1-like C-terminal motif

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0008017   microtubule binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 162 1wyo (A) 8 159 62.00 0 1 1.30774 -0.57
14 126 1v5k (A) 2 114 59.00 0 1 1.17782 -0.91
22 276 1pxy (A) 126 397 17.00 0 1 0.890313 0.51

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127230)

Species Accession Gene Product
Arabidopsis thaliana AT5G62500   microtubule-associated protein, RP/EB family member 1B
Arabidopsis thaliana AT5G67270   microtubule-associated protein RP/EB family member 1C
Arabidopsis thaliana AT3G47690   microtubule end binding protein EB1A
Babesia bovis BBOV_III000990   microtubule-associated protein RP/EB family member protein
Brugia malayi Bm1_50270   EBF3-S
Candida albicans CaO19.8293   probable microtubule-binding protein similar to S. cerevisiae BIM1 (YER016W)
Candida albicans CaO19.676   probable microtubule-binding protein similar to S. cerevisiae BIM1 (YER016W)
Caenorhabditis elegans CELE_Y59A8B.9   Protein EBP-3
Caenorhabditis elegans CELE_Y59A8B.7   Protein EBP-1
Cryptosporidium hominis Chro.70271   microtubule-associated protein
Cryptosporidium parvum cgd7_2370   EB1 like microtubule binding protein
Dictyostelium discoideum DDB_G0283607   microtubule-associated protein EB1
Drosophila melanogaster Dmel_CG3265   CG3265 gene product from transcript CG3265-RF
Drosophila melanogaster Dmel_CG32371   CG32371 gene product from transcript CG32371-RA
Drosophila melanogaster Dmel_CG18190   CG18190 gene product from transcript CG18190-RB
Echinococcus granulosus EgrG_000637300   Microtubule associated protein RP:EB family
Echinococcus multilocularis EmuJ_000637300   Microtubule associated protein RP:EB family
Giardia lamblia GL50803_14048   EB1
Homo sapiens ENSG00000101367   microtubule-associated protein, RP/EB family, member 1
Homo sapiens ENSG00000166974   microtubule-associated protein, RP/EB family, member 2
Loa Loa (eye worm) LOAG_03147   EBF3-S
Loa Loa (eye worm) LOAG_13950   microtubule binding protein
Mus musculus ENSMUSG00000027479   microtubule-associated protein, RP/EB family, member 1
Mus musculus ENSMUSG00000024277   microtubule-associated protein, RP/EB family, member 2
Neospora caninum NCLIV_045630   APC binding protein EB1, related
Oryza sativa 4349023   Os10g0498900
Oryza sativa 4337174   Os04g0642100
Onchocerca volvulus OVOC12880  
Plasmodium berghei PBANKA_0405600   microtubule-associated protein RP/EB family, putative
Plasmodium falciparum PF3D7_0307300   microtubule-associated protein RP/EB family, putative
Plasmodium knowlesi PKNH_0835400   microtubule-associated protein RP/EB family, putative
Plasmodium vivax PVX_119485   microtubule associated protein EB1, putative
Plasmodium yoelii PY06631   Putative homologue of Human EB1 protein-related
Saccharomyces cerevisiae YER016W   Bim1p
Schistosoma japonicum Sjp_0085580   ko:K10436 microtubule-associated protein, RP/EB family, putative
Schistosoma mansoni Smp_054540   microtubule-associated protein rp/eb family
Schmidtea mediterranea mk4.000575.05   Putative microtubule-associated protein, rp/eb family
Schmidtea mediterranea mk4.000046.05   Putative microtubule-associated protein, rp/eb family
Schmidtea mediterranea mk4.000729.04   Putative microtubule-associated protein, rp/eb family
Toxoplasma gondii TGME49_227650   microtubule-associated protein RP/EB family, putative
Theileria parva TP03_0743   microtubule associated protein, putative
Trichomonas vaginalis TVAG_146390   conserved hypothetical protein
Trichomonas vaginalis TVAG_228400   conserved hypothetical protein
Trichomonas vaginalis TVAG_266680   conserved hypothetical protein
Trichomonas vaginalis TVAG_381030   conserved hypothetical protein

Essentiality

Smp_054540 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YER016W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0405600 Plasmodium berghei Dispensable plasmo
TGME49_227650 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_054540 (Schistosoma mansoni), microtubule-associated protein rp/eb family
Title for this comment
Comment