pI: 6.2282 |
Length (AA): 850 |
MW (Da): 93997 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
58 | 746 | 1pcx (A) | 134 | 813 | 18.00 | 0 | 1 | 0.92 | -0.18 |
110 | 850 | 1pd0 (A) | 170 | 926 | 17.00 | 0 | 1 | 0.81 | -0.38 |
114 | 849 | 1m2o (A) | 3 | 765 | 39.00 | 0 | 1 | 1.41 | -1.35 |
76 | 845 | 1m2v (B) | 66 | 922 | 17.00 | 0 | 1 | 0.912982 | 0.31 |
114 | 849 | 5kyn (A) | 8 | 762 | 38.00 | 0 | 1 | 1.36598 | -0.65 |
121 | 849 | 1m2o (A) | 14 | 765 | 38.00 | 0 | 1 | 1.32415 | -0.57 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_127203)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G43670 | sec23/sec24-like transport protein |
Arabidopsis thaliana | AT1G05520 | sec23/sec24-like transport protein |
Arabidopsis thaliana | AT3G23660 | Sec23/Sec24 protein transport family protein |
Arabidopsis thaliana | AT4G14160 | sec23/sec24-like transport protein |
Arabidopsis thaliana | AT2G21630 | sec23/sec24-like transport protein |
Babesia bovis | BBOV_II007590 | sec23 protein |
Brugia malayi | Bm1_52435 | putative Sec23 protein |
Candida albicans | CaO19.1254 | one of three genes similar to S. cerevisiae SEC23 (YPR181C) cytoplasmic GTPase-activating protein involved in COP II vesicle coa |
Candida albicans | CaO19.8839 | one of three genes similar to S. cerevisiae SEC23 (YPR181C) cytoplasmic GTPase-activating protein involved in COP II vesicle coa |
Caenorhabditis elegans | CELE_Y113G7A.3 | Protein SEC-23 |
Cryptosporidium hominis | Chro.30216 | transport protein |
Cryptosporidium parvum | cgd3_1820 | putative Sec23 |
Dictyostelium discoideum | DDB_G0281985 | hypothetical protein |
Drosophila melanogaster | Dmel_CG1250 | Sec23 ortholog (S. cerevisiae) |
Echinococcus granulosus | EgrG_000529300 | protein transport protein Sec23A |
Entamoeba histolytica | EHI_008730 | Sec23 protein, putative |
Entamoeba histolytica | EHI_175480 | Sec23 protein, putative |
Echinococcus multilocularis | EmuJ_000529300 | protein transport protein Sec23A |
Giardia lamblia | GL50803_9376 | Sec23 |
Homo sapiens | ENSG00000100934 | Sec23 homolog A (S. cerevisiae) |
Homo sapiens | ENSG00000101310 | Sec23 homolog B (S. cerevisiae) |
Leishmania braziliensis | LbrM.35.6760 | protein transport protein Sec23-like protein |
Leishmania donovani | LdBPK_366710.1 | protein transport protein Sec23-like protein |
Leishmania infantum | LinJ.36.6710 | protein transport protein Sec23-like protein |
Leishmania major | LmjF.36.6430 | protein transport protein Sec23-like protein |
Leishmania mexicana | LmxM.36.6430 | protein transport protein Sec23-like protein |
Loa Loa (eye worm) | LOAG_03100 | hypothetical protein |
Mus musculus | ENSMUSG00000027429 | SEC23B (S. cerevisiae) |
Mus musculus | ENSMUSG00000020986 | SEC23A (S. cerevisiae) |
Neospora caninum | NCLIV_043180 | hypothetical protein |
Oryza sativa | 4347283 | Os09g0460200 |
Oryza sativa | 4334068 | Os03g0742800 |
Oryza sativa | 4345819 | Os08g0474700 |
Plasmodium berghei | PBANKA_0708000 | protein transport protein SEC23, putative |
Plasmodium falciparum | PF3D7_0822600 | protein transport protein SEC23 |
Plasmodium knowlesi | PKNH_1316600 | protein transport protein SEC23, putative |
Plasmodium vivax | PVX_089235 | protein transport protein SEC23, putative |
Plasmodium yoelii | PY02497 | putative Sec23 protein |
Saccharomyces cerevisiae | YPR181C | GTPase-activating protein SEC23 |
Schistosoma japonicum | Sjp_0007260 | Protein transport protein Sec23A, putative |
Schistosoma japonicum | Sjp_0317160 | Protein transport protein Sec23A, putative |
Schistosoma mansoni | Smp_099310 | protein transport protein sec23 |
Schmidtea mediterranea | mk4.001214.01 | |
Trypanosoma brucei gambiense | Tbg972.10.9490 | protein transport protein Sec23A, putative |
Trypanosoma brucei | Tb927.10.7740 | protein transport protein SEC23 |
Trypanosoma congolense | TcIL3000_10_6600 | protein transport protein Sec23A, putative |
Trypanosoma cruzi | TcCLB.508231.230 | protein transport protein Sec23A, putative |
Trypanosoma cruzi | TcCLB.506249.20 | protein transport protein Sec23A, putative |
Toxoplasma gondii | TGME49_291680 | Sec23/Sec24 trunk domain-containing protein |
Theileria parva | TP02_0701 | Sec23, putative |
Trichomonas vaginalis | TVAG_038520 | protein transport protein sec23, putative |
Trichomonas vaginalis | TVAG_078060 | protein transport protein sec23, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.7740 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.7740 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.7740 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.7740 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y113G7A.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y113G7A.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y113G7A.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y113G7A.3 | Caenorhabditis elegans | sterile | wormbase |
YPR181C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0708000 | Plasmodium berghei | Essential | plasmo |
TGME49_291680 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.