pI: 10.242 |
Length (AA): 915 |
MW (Da): 91608 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
726 | 905 | 2jax (A) | 115 | 293 | 20.00 | 0 | 1 | 0.409421 | -0.29 |
747 | 830 | 2zue (A) | 364 | 451 | 37.00 | 0.47 | 0.16 | 0.248903 | 0.98 |
759 | 905 | 1mjh (A) | 6 | 158 | 18.00 | 0 | 0.99 | 0.417356 | -0.85 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128869)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_25655 | SRP40, C-terminal domain containing protein |
Candida albicans | CaO19.10377 | similar to nucleolar snoRNP chaperone component |
Candida albicans | CaO19.2859 | similar to nucleolar snoRNP chaperone component |
Candida albicans | CaO19.3091 | hypothetical protein |
Candida albicans | CaO19.10603 | hypothetical protein |
Caenorhabditis elegans | CELE_C25A1.10 | Protein DAO-5, isoform B |
Dictyostelium discoideum | DDB_G0291444 | hypothetical protein |
Drosophila melanogaster | Dmel_CG7421 | CG7421 gene product from transcript CG7421-RE |
Echinococcus granulosus | EgrG_001076900 | universal stress protein |
Echinococcus granulosus | EgrG_000725800 | universal stress protein |
Echinococcus multilocularis | EmuJ_001076900 | universal stress protein |
Echinococcus multilocularis | EmuJ_000725800 | universal stress protein |
Giardia lamblia | GL50803_8627 | Hypothetical protein |
Homo sapiens | ENSG00000166197 | nucleolar and coiled-body phosphoprotein 1 |
Loa Loa (eye worm) | LOAG_05089 | hypothetical protein |
Mus musculus | ENSMUSG00000015176 | nucleolar and coiled-body phosphoprotein 1 |
Neospora caninum | NCLIV_002810 | hypothetical protein |
Saccharomyces cerevisiae | YKR092C | Srp40p |
Schistosoma japonicum | Sjp_0096880 | IPR006015,Universal stress protein (Usp);IPR006016,UspA,domain-containing |
Schistosoma japonicum | Sjp_0306470 | IPR006015,Universal stress protein (Usp);IPR006016,UspA,domain-containing |
Schistosoma japonicum | Sjp_0003950 | IPR006015,Universal stress protein (Usp);IPR006016,UspA,domain-containing |
Schistosoma japonicum | Sjp_0047310 | IPR007718,SRP40, C-terminal,domain-containing |
Schistosoma mansoni | Smp_001010 | hypothetical protein |
Schistosoma mansoni | Smp_110280 | hypothetical protein |
Schistosoma mansoni | Smp_126090 | hypothetical protein |
Trypanosoma brucei gambiense | Tbg972.8.3590 | hypothetical protein, conserved |
Trypanosoma brucei | Tb11.v5.0681 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.8.3870 | SRP40, C-terminal domain containing protein, putative |
Trypanosoma congolense | TcIL3000_8_3750 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.503905.30 | SRP40, C-terminal domain containing protein, putative |
Trypanosoma cruzi | TcCLB.507705.30 | SRP40, C-terminal domain containing protein, putative |
Trichomonas vaginalis | TVAG_176990 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_083140 | protein SED4, putative |
Trichomonas vaginalis | TVAG_153300 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.3870 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.3870 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.3870 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.3870 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C25A1.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C25A1.10 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C25A1.10 | Caenorhabditis elegans | larval lethal | wormbase |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.