Detailed view for Smp_141040

Basic information

TDR Targets ID: 292255
Schistosoma mansoni, striatin
Source Database / ID:  GeneDB

pI: 5.0343 | Length (AA): 815 | MW (Da): 91364 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat
PF08232   Striatin family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
58 103 4n6j (A) 85 130 65.00 0 0.12 0.631142 0.02
60 280 5cwp (A) 5 227 14.00 0.03 0.08 0.419866 -0.72
376 785 3dm0 (A) 294 1294 27.00 0.00011 1 0.564267 0.93
462 814 6g6m (A) 6 276 28.00 0 1 0.447329 0.5
701 814 4j0w (A) 148 268 29.00 0.001 0.82 0.435077 -0.29
702 808 6f9n (B) 247 353 40.00 0.0000000047 1 0.537488 0.08
712 814 6chg (A) 123 230 27.00 0.0016 0.89 0.42258 0.07
713 776 4u1e (I) 24 87 25.00 0.37 0.57 0.407728 -0.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128956)

Species Accession Gene Product
Brugia malayi Bm1_52045   Striatin 3
Caenorhabditis elegans CELE_K07C5.8   Protein CASH-1
Dictyostelium discoideum DDB_G0288327   WD40 repeat-containing protein
Drosophila melanogaster Dmel_CG7392   Connector of kinase to AP-1
Echinococcus granulosus EgrG_000121400   striatin
Echinococcus granulosus EgrG_000466700   striatin
Echinococcus multilocularis EmuJ_000121400   striatin
Echinococcus multilocularis EmuJ_000466700   striatin
Homo sapiens ENSG00000196792   striatin, calmodulin binding protein 3
Homo sapiens ENSG00000090372   striatin, calmodulin binding protein 4
Homo sapiens ENSG00000115808   striatin, calmodulin binding protein
Loa Loa (eye worm) LOAG_04706   hypothetical protein
Mus musculus ENSMUSG00000024077   striatin, calmodulin binding protein
Mus musculus ENSMUSG00000030374   striatin, calmodulin binding protein 4
Mus musculus ENSMUSG00000020954   striatin, calmodulin binding protein 3
Schistosoma japonicum Sjp_0099000   Striatin-3, putative
Schistosoma japonicum Sjp_0042010   Striatin, putative
Schistosoma japonicum Sjp_0133750   Striatin, putative
Schistosoma japonicum Sjp_0309850   Striatin-3, putative
Schistosoma japonicum Sjp_0316570   Striatin-3, putative
Schistosoma mansoni Smp_166080.1   striatin
Schistosoma mansoni Smp_166080.2   striatin
Schistosoma mansoni Smp_141040   striatin
Schmidtea mediterranea mk4.001496.01   Connector of kinase to AP-1
Schmidtea mediterranea mk4.002691.03  
Schmidtea mediterranea mk4.001496.03  
Schmidtea mediterranea mk4.003226.00  
Schmidtea mediterranea mk4.002691.05  
Schmidtea mediterranea mk4.001048.02  
Trichomonas vaginalis TVAG_063820   striatin, putative
Trichomonas vaginalis TVAG_178730   striatin, putative

Essentiality

Smp_141040 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K07C5.8 Caenorhabditis elegans larval arrest wormbase
CELE_K07C5.8 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_141040 (Schistosoma mansoni), striatin
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