Detailed view for Smp_183260

Basic information

TDR Targets ID: 292354
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 4.47 | Length (AA): 185 | MW (Da): 21372 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 45 3isr (A) 161 208 27.00 0.24 0.29 0.313938 1.26
55 130 4n9j (A) 730 803 34.00 0.83 0.26 0.798711 -0.48

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130035)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG34110   lost boys
Echinococcus granulosus EgrG_000556500   coiled coil domain containing protein 135
Echinococcus multilocularis EmuJ_000556500   coiled coil domain containing protein 135
Homo sapiens ENSG00000159625   dynein regulatory complex subunit 7
Leishmania braziliensis LbrM.05.1020   hypothetical protein, conserved
Leishmania donovani LdBPK_051020.1   hypothetical protein, conserved
Leishmania infantum LinJ.05.1020   hypothetical protein, conserved
Leishmania major LmjF.05.1020   hypothetical protein, conserved
Leishmania mexicana LmxM.05.1020   hypothetical protein, conserved
Mus musculus ENSMUSG00000031786   dynein regulatory complex subunit 7
Neospora caninum NCLIV_013450   hypothetical protein, conserved
Plasmodium berghei PBANKA_1444600   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1229900   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_1449300   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_124130   hypothetical protein, conserved
Plasmodium yoelii PY02515   hypothetical protein
Schistosoma japonicum Sjp_0036640   Coiled-coil domain-containing protein 135, putative
Schistosoma mansoni Smp_183260   hypothetical protein
Trypanosoma brucei gambiense Tbg972.5.510   hypothetical protein, conserved
Trypanosoma brucei Tb11.v5.0218   hypothetical protein, conserved
Trypanosoma brucei Tb927.5.500   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_5_150   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509885.50   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508397.50   hypothetical protein, conserved
Toxoplasma gondii TGME49_213720   hypothetical protein
Trichomonas vaginalis TVAG_293030   conserved hypothetical protein

Essentiality

Smp_183260 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.500 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.500 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.5.500 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.500 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1444600 Plasmodium berghei Slow plasmo
TGME49_213720 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_183260 (Schistosoma mansoni), hypothetical protein
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