Detailed view for Smp_159170

Basic information

TDR Targets ID: 292478
Schistosoma mansoni, nuclear lim interactor-interacting factor-related
Source Database / ID:  GeneDB

pI: 6.8008 | Length (AA): 441 | MW (Da): 50116 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03031   NLI interacting factor-like phosphatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016791   phosphoric monoester hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 247 4n5a (A) 332 558 9.00 0 0.02 0.58975 -0.39
266 432 2hhl (A) 6 168 42.00 0 1 0.858485 -0.18
279 436 2ght (A) 77 234 45.00 0 1 0.928177 -0.56
283 435 2q5e (A) 91 244 46.00 0 1 0.949739 -0.84
285 379 4xpz (A) 157 268 35.00 0.000000031 0.98 0.46422 0.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130261)

Species Accession Gene Product
Arabidopsis thaliana AT5G11860   SCP1-like small phosphatase 5
Brugia malayi Bm1_35985   NLI interacting factor-like phosphatase family protein
Caenorhabditis elegans CELE_Y47D9A.2   Protein SCPL-3, isoform B
Cryptosporidium hominis Chro.40368   ENSANGP00000011443
Cryptosporidium parvum cgd4_3240   possible NLI interacting factor CTD-like phosphatase
Dictyostelium discoideum DDB_G0290365   CTD small phosphatase-like protein 2
Echinococcus granulosus EgrG_001061300   CTD small phosphatase protein 2
Echinococcus multilocularis EmuJ_001061300   CTD small phosphatase protein 2
Homo sapiens ENSG00000137770   CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
Leishmania braziliensis LbrM.26.0150   nuclear lim interactor-interacting factor-like protein
Leishmania donovani LdBPK_260140.1   nuclear lim interactor-interacting factor-like protein
Leishmania infantum LinJ.26.0140   nuclear lim interactor-interacting factor-like protein
Leishmania major LmjF.26.0160   nuclear lim interactor-interacting factor-like protein
Leishmania mexicana LmxM.26.0160   nuclear lim interactor-interacting factor-like protein
Loa Loa (eye worm) LOAG_03651   SCP small domain phosphatase
Mus musculus ENSMUSG00000033411   CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
Neospora caninum NCLIV_024550   Zgc:77714, related
Oryza sativa 4334791   Os03g0850100
Schistosoma japonicum Sjp_0034690   CTD small phosphatase-like protein 2, putative
Schistosoma mansoni Smp_159170   nuclear lim interactor-interacting factor-related
Schmidtea mediterranea mk4.005794.00   Nuclear lim interactor-interacting factor-related
Toxoplasma gondii TGME49_263380   Dullard family phosphatase domain-containing protein

Essentiality

Smp_159170 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_263380 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_159170 (Schistosoma mansoni), nuclear lim interactor-interacting factor-related
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