Detailed view for Smp_082780

Basic information

TDR Targets ID: 292533
Schistosoma mansoni, wiskott-aldrich syndrome protein
Source Database / ID:  GeneDB

pI: 8.9347 | Length (AA): 482 | MW (Da): 51906 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00568   WH1 domain
PF00786   P21-Rho-binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0015629   actin cytoskeleton  
GO:0005515   protein binding  
GO:0005083   small GTPase regulator activity  
GO:0008154   actin polymerization and/or depolymerization  
GO:0006461   protein complex assembly  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
29 156 2ifs (A) 518 645 32.00 0 0.98 0.60236 0.41
42 144 5ncg (A) 1 106 18.00 0.0001 0.87 0.447393 -0.34
83 149 3syx (A) 57 123 30.00 0.36 0.58 0.461504 0.29
255 432 3au4 (A) 1501 1681 9.00 0 0.03 0.470495 -0.54
279 479 3wmt (A) 66 272 13.00 0 0.1 0.492812 -0.06
318 356 1nay (A) 107 132 65.00 0.26 0.3 0.234413 0.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128991)

Species Accession Gene Product
Brugia malayi Bm1_29495   WH1 domain containing protein
Candida albicans CaO19.6598   similar to S. cerevisiae LAS17 (YOR181W) actin assembly factor
Caenorhabditis elegans CELE_C07G1.4   Protein WSP-1, isoform B
Dictyostelium discoideum DDB_G0281723   WH2 domain-containing protein
Dictyostelium discoideum DDB_G0272811   WASP-related protein
Dictyostelium discoideum DDB_G0293834   Wiscott-Aldrich syndrome protein
Drosophila melanogaster Dmel_CG1520   CG1520 gene product from transcript CG1520-RA
Echinococcus granulosus EgrG_001173500   neural Wiskott Aldrich syndrome protein
Echinococcus multilocularis EmuJ_000845000   wiskott Aldrich syndrome protein
Echinococcus multilocularis EmuJ_001173500   neural Wiskott Aldrich syndrome protein
Homo sapiens ENSG00000106299   Wiskott-Aldrich syndrome-like
Homo sapiens ENSG00000015285   Wiskott-Aldrich syndrome
Loa Loa (eye worm) LOAG_04947   hypothetical protein
Mus musculus ENSMUSG00000031165   Wiskott-Aldrich syndrome homolog (human)
Mus musculus ENSMUSG00000029684   Wiskott-Aldrich syndrome-like (human)
Saccharomyces cerevisiae YOR181W   Las17p
Schistosoma japonicum Sjp_0205390   IPR011993,Pleckstrin homology-type;IPR000697,EVH1,domain-containing
Schistosoma mansoni Smp_082780   wiskott-aldrich syndrome protein
Schmidtea mediterranea mk4.009748.04  
Schmidtea mediterranea mk4.008632.02  
Schmidtea mediterranea mk4.020549.00  
Schmidtea mediterranea mk4.010220.00  
Trichomonas vaginalis TVAG_496150   conserved hypothetical protein
Trichomonas vaginalis TVAG_283280   conserved hypothetical protein

Essentiality

Smp_082780 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C07G1.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_C07G1.4 Caenorhabditis elegans larval arrest wormbase
CELE_C07G1.4 Caenorhabditis elegans sterile wormbase
YOR181W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Neural Wiskott-Aldrich syndrome protein Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0115 0.3638 0.3558
0.0121 0.3953 0.3571
0.0379 0.3509 0.3509
0.0467 0.3945 0.3945
0.0413 0.2788 0.2788
0.0115 0.3638 0.3558
0.0496 0.3202 0.3201
0.0413 0.2788 0.2788
0.0045 0.3885 0.3885
0.0413 0.2788 0.2788
0.0157 0.2944 0.2944
0.0101 0.3503 0.3503
0.0122 0.356 0.356
0.0483 0.2668 0.2774
0.0496 0.3202 0.3201
0.0496 0.3202 0.3201
0.0121 0.3687 0.3687
0.0496 0.3202 0.3201
0.0148 0.3588 0.3588
0.0397 0.2969 0
0.0164 0.3637 0.3637
0.038 0.4073 0.4019
0.041 0.4055 0.4055
0.0307 0.4052 0.3984
0.0115 0.3638 0.3558
0.0483 0.2668 0.2774
0.0413 0.2788 0.2788
0.0136 0.3726 0.3671
0.0413 0.2788 0.2788
0.041 0.4055 0.4055
0.041 0.4299 0.4299
0.0483 0.2668 0.2774
0.0049 0.2582 0.2582
0.0207 0.4053 0.4053
0.0412 0.3368 0.2254
0.0483 0.2668 0.2774
0.0413 0.2788 0.2788
0.041 0.4299 0.4299
0.0117 0.3826 0.3784
0.0211 0.3956 0.3921
0.0166 0.2848 0.2848
0.0123 0.355 0.355
0.0135 0.3693 0.3629
0.0121 0.3687 0.3687
0.0216 0.3571 0.3571
0.012 0.3671 0.4313
0.0113 0.3874 0.3874
0.0413 0.4031 0.4031
0.0426 0.3821 0.3821
0.0135 0.3739 0.3689

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_082780 (Schistosoma mansoni), wiskott-aldrich syndrome protein
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