Detailed view for Smp_180470

Basic information

TDR Targets ID: 292667
Schistosoma mansoni, cytoplasmic dynein intermediate chain 2 (dhic-2)
Source Database / ID:  GeneDB

pI: 4.79 | Length (AA): 646 | MW (Da): 72330 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF11540   Cytoplasmic dynein 1 intermediate chain 2

Gene Ontology

Mouse over links to read term descriptions.
GO:0005868   cytoplasmic dynein complex  
GO:0005515   protein binding  
GO:0007018   microtubule-based movement  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
262 581 6g6o (A) 19 305 22.00 0 1 0.475156 0.24
467 553 4j73 (A) 91 172 26.00 0.32 0.68 0.452275 -0.82
471 531 4wjs (A) 144 199 41.00 0.46 0.82 0.512027 -0.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128302)

Species Accession Gene Product
Brugia malayi Bm1_52885   cytoplasmic dynein intermediate chain 1
Candida albicans CaO19.7632   similar to cytoplasmic dynein intermediate chain 2C
Caenorhabditis elegans CELE_C17H12.1   Protein DYCI-1
Cryptosporidium hominis Chro.10178   dynein intermediate chain 2, cytosolic
Cryptosporidium parvum cgd1_1540   dynein intermediate chain
Dictyostelium discoideum DDB_G0280849   cytoplasmic dynein intermediate chain
Drosophila melanogaster Dmel_CG9580   Sperm-specific dynein intermediate chain 1
Drosophila melanogaster Dmel_CG33499   Sperm-specific dynein intermediate chain 4
Drosophila melanogaster Dmel_CG32823   Sperm-specific dynein intermediate chain 3
Drosophila melanogaster Dmel_CG33497   Sperm-specific dynein intermediate chain 2
Drosophila melanogaster Dmel_CG18000   short wing
Echinococcus granulosus EgrG_000131500   Dynein intermediate chain
Echinococcus granulosus EgrG_000585700   Dynein intermediate chain
Echinococcus granulosus EgrG_000582800   Dynein intermediate chain
Echinococcus multilocularis EmuJ_000131500   Dynein intermediate chain
Echinococcus multilocularis EmuJ_000582800   Dynein intermediate chain
Echinococcus multilocularis EmuJ_000585700   Dynein intermediate chain
Homo sapiens ENSG00000077380   dynein, cytoplasmic 1, intermediate chain 2
Homo sapiens ENSG00000158560   dynein, cytoplasmic 1, intermediate chain 1
Loa Loa (eye worm) LOAG_04904   cytoplasmic dynein intermediate chain 1
Mus musculus ENSMUSG00000029757   dynein cytoplasmic 1 intermediate chain 1
Mus musculus ENSMUSG00000027012   dynein cytoplasmic 1 intermediate chain 2
Neospora caninum NCLIV_068370   dynein intermediate chain, putative
Plasmodium berghei PBANKA_0504500   cytoplasmic dynein intermediate chain, putative
Plasmodium falciparum PF3D7_1020300   cytoplasmic dynein intermediate chain, putative
Plasmodium knowlesi PKNH_0604500   cytoplasmic dynein intermediate chain, putative
Plasmodium vivax PVX_001875   cytoplasmic dynein intermediate chain, putative
Plasmodium yoelii PY00602   dynein intermediate chain 2, cytosolic
Schistosoma japonicum Sjp_0010830   ko:K10415 dynein intermediate chain, cytosolic, putative
Schistosoma japonicum Sjp_0100350   Cytoplasmic dynein 1 intermediate chain 2, putative
Schistosoma japonicum Sjp_0097700   Dynein intermediate chain, cytosolic, putative
Schistosoma mansoni Smp_180470   cytoplasmic dynein intermediate chain 2 (dhic-2)
Schistosoma mansoni Smp_064870   cytoplasmic dynein intermediate chain 2 (dhic-2)
Schmidtea mediterranea mk4.004330.03  
Schmidtea mediterranea mk4.016142.01  
Schmidtea mediterranea mk4.004330.01  
Schmidtea mediterranea mk4.003284.03  
Toxoplasma gondii TGME49_277510   cytoplasmic dynein intermediate chain

Essentiality

Smp_180470 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C17H12.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_C17H12.1 Caenorhabditis elegans larval arrest wormbase
CELE_C17H12.1 Caenorhabditis elegans slow growth wormbase
CELE_C17H12.1 Caenorhabditis elegans sterile wormbase
TGME49_277510 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Smp_180470 (Schistosoma mansoni), cytoplasmic dynein intermediate chain 2 (dhic-2)
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