Detailed view for Smp_031920.1

Basic information

TDR Targets ID: 292729
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 5.9759 | Length (AA): 252 | MW (Da): 28160 | Paralog Number: 7

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03194   LUC7 N_terminus

Gene Ontology

Mouse over links to read term descriptions.
GO:0006376   mRNA splice site selection  
GO:0005685   snRNP U1  
GO:0003729   mRNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
63 180 3k29 (A) 31 150 16.00 0.15 0.01 0.683454 -0.82
89 174 4oog (A) 54 148 35.00 0.23 0.18 0.56707 0.35

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127248)

Species Accession Gene Product
Arabidopsis thaliana AT5G51410   LUC7 N_terminus domain-containing protein
Babesia bovis BBOV_II005650   conserved hypothetical protein
Brugia malayi Bm1_53165   Hypothetical 37.0 kDa protein B0495.8 in chromosome II, putative
Brugia malayi Bm1_55660   putative salt tolerance protein
Candida albicans CaO19.3116   interacts with cap-binding complex
Candida albicans CaO19.10628   interacts with cap-binding complex
Caenorhabditis elegans CELE_C50D2.8   Protein C50D2.8
Caenorhabditis elegans CELE_B0495.8   Protein B0495.8, isoform B
Cryptosporidium hominis Chro.60294   hypothetical protein
Cryptosporidium parvum cgd6_2550   conserved hypothetical protein
Dictyostelium discoideum DDB_G0278799   Luc7 family protein
Drosophila melanogaster Dmel_CG7564   CG7564 gene product from transcript CG7564-RD
Echinococcus granulosus EgrG_000201900   LUC7
Echinococcus granulosus EgrG_000582100   LUC7
Echinococcus multilocularis EmuJ_000582100   LUC7
Echinococcus multilocularis EmuJ_000201900   LUC7
Homo sapiens 100996928   C7orf55-LUC7L2 readthrough
Homo sapiens ENSG00000146963   LUC7-like 2 (S. cerevisiae)
Homo sapiens ENSG00000007392   LUC7-like (S. cerevisiae)
Homo sapiens ENSG00000108848   LUC7-like 3 (S. cerevisiae)
Loa Loa (eye worm) LOAG_00023   hypothetical protein
Loa Loa (eye worm) LOAG_07603   hypothetical protein
Mus musculus ENSMUSG00000024188   Luc7 homolog (S. cerevisiae)-like
Mus musculus ENSMUSG00000020863   LUC7-like 3 (S. cerevisiae)
Mus musculus ENSMUSG00000029823   LUC7-like 2 (S. cerevisiae)
Neospora caninum NCLIV_024960   hypothetical protein
Neospora caninum NCLIV_011870   hypothetical protein
Oryza sativa 4343144   Os07g0456400
Onchocerca volvulus OVOC10365  
Plasmodium berghei PBANKA_1316400   U1 snRNA associated protein, putative
Plasmodium falciparum PF3D7_1452700   U1 snRNA associated protein, putative
Plasmodium knowlesi PKNH_1229400   U1 snRNA associated protein, putative
Plasmodium vivax PVX_117845   hypothetical protein, conserved
Plasmodium yoelii PY04945   cisplatin resistance-associated overexpressed protein-related
Saccharomyces cerevisiae YDL087C   Luc7p
Schistosoma japonicum Sjp_0103100   Cisplatin resistance-associated overexpressed protein, putative
Schistosoma japonicum Sjp_0034440   Putative RNA-binding protein Luc7-like 2, putative
Schistosoma japonicum Sjp_0217690   expressed protein
Schistosoma mansoni Smp_031920.5   hypothetical protein
Schistosoma mansoni Smp_031920.1   hypothetical protein
Schistosoma mansoni Smp_031920.7   hypothetical protein
Schistosoma mansoni Smp_031920.3   hypothetical protein
Schistosoma mansoni Smp_015850.3   hypothetical protein
Schistosoma mansoni Smp_015850.2   hypothetical protein
Schistosoma mansoni Smp_031920.2   hypothetical protein
Schistosoma mansoni Smp_031920.4   hypothetical protein
Schmidtea mediterranea mk4.001787.02  
Schmidtea mediterranea mk4.001117.00  
Schmidtea mediterranea mk4.000600.04  
Schmidtea mediterranea mk4.025822.00  
Schmidtea mediterranea mk4.006449.00  
Schmidtea mediterranea mk4.010553.02  
Toxoplasma gondii TGME49_262960   U1 snRNP-associated protein Usp106, putative
Toxoplasma gondii TGME49_210980   alternative splicing type 3 and, putative
Theileria parva TP02_0516   hypothetical protein
Trichomonas vaginalis TVAG_030410   exm2 protein, putative

Essentiality

Smp_031920.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_B0495.8 Caenorhabditis elegans embryonic lethal wormbase
YDL087C Saccharomyces cerevisiae inviable yeastgenome
TGME49_262960 Toxoplasma gondii Probably essential sidik
TGME49_210980 Toxoplasma gondii Probably essential sidik
TGME49_262960 Toxoplasma gondii Probably non-essential sidik
TGME49_210980 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_031920.1 (Schistosoma mansoni), hypothetical protein
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