Detailed view for Smp_162270

Basic information

TDR Targets ID: 292744
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 6.3247 | Length (AA): 183 | MW (Da): 20883 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07542   ATP12 chaperone protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0043461   proton-transporting ATP synthase complex assembly  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 169 2r6i (A) 94 260 19.00 0 1 1.27777 -1.02
3 174 2r31 (A) 72 232 31.00 0 1 1.36069 -0.79
111 148 2ond (A) 411 446 36.00 0.79 0.16 0.46145 0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128946)

Species Accession Gene Product
Arabidopsis thaliana AT5G40660   ATP12 protein-related
Brugia malayi Bm1_18600   ATP synthase mitochondrial F1 complex assembly factor 2
Candida albicans CaO19.11170   F1-ATP synthase assembly protein
Candida albicans CaO19.3686   F1-ATP synthase assembly protein
Caenorhabditis elegans CELE_Y116A8C.27   Protein Y116A8C.27, isoform B
Dictyostelium discoideum DDB_G0292678   ATP synthase mitochondrial F1 complex assembly factor 2
Drosophila melanogaster Dmel_CG8674   lethal (2) k14505
Echinococcus granulosus EgrG_000189000   ATP synthase mitochondrial F1 complex assembly
Echinococcus multilocularis EmuJ_000189000   ATP synthase mitochondrial F1 complex assembly
Homo sapiens ENSG00000171953   ATP synthase mitochondrial F1 complex assembly factor 2
Leishmania braziliensis LbrM.18.0370   hypothetical protein, conserved
Leishmania donovani LdBPK_180350.1   ATP12 chaperone protein, putative
Leishmania infantum LinJ.18.0350   hypothetical protein, conserved
Leishmania major LmjF.18.0350   hypothetical protein, conserved
Leishmania mexicana LmxM.18.0350   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_05675   hypothetical protein
Mus musculus ENSMUSG00000042709   ATP synthase mitochondrial F1 complex assembly factor 2
Oryza sativa 4344085   Os07g0644000
Onchocerca volvulus OVOC10138   ATP synthase mitochondrial F1 complex assembly factor 2 homolog
Saccharomyces cerevisiae YJL180C   Atp12p
Schistosoma japonicum Sjp_0207940   ko:K07556 ATP synthase mitochondrial F1 complex assembly factor 2, putative
Schistosoma mansoni Smp_162270   hypothetical protein
Schmidtea mediterranea mk4.001219.00  
Schmidtea mediterranea mk4.004373.01   ATP synthase mitochondrial F1 complex assembly factor 2
Trypanosoma brucei gambiense Tbg972.10.17030   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.13850   ATP12 chaperone protein, putative
Trypanosoma congolense TcIL3000_10_11830   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511277.460   ATP12 chaperone protein, putative
Trypanosoma cruzi TcCLB.507993.10   ATP12 chaperone protein, putative

Essentiality

Smp_162270 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.13850 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.13850 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.13850 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.13850 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_162270 (Schistosoma mansoni), hypothetical protein
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