Detailed view for Smp_007960

Basic information

TDR Targets ID: 292756
Schistosoma mansoni, 4-hydroxyphenylpyruvate dioxygenase
Source Database / ID:  GeneDB

pI: 4.4605 | Length (AA): 345 | MW (Da): 38924 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00903   Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0016701   oxidoreductase activity, acting on single donors with incorporation of molecular oxygen  
GO:0003868   4-hydroxyphenylpyruvate dioxygenase activity  
GO:0055114   oxidation reduction  
GO:0009072   aromatic amino acid family metabolic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 345 3isq (A) 64 377 27.00 0 1 1.1974 0.42
8 345 3isq (A) 71 377 34.00 0 1 1.22911 0.35
26 343 1t47 (A) 95 375 31.00 0 1 1.18224 0.02
85 344 2r5v (B) 97 347 25.00 0 1 0.991123 -0.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_137819)

Species Accession Gene Product
Homo sapiens ENSG00000186603   4-hydroxyphenylpyruvate dioxygenase-like
Mus musculus ENSMUSG00000043155   4-hydroxyphenylpyruvate dioxygenase-like
Schistosoma japonicum Sjp_0210970   ko:K00457 4-hydroxyphenylpyruvate dioxygenase [EC1.13.11.27], putative
Schistosoma mansoni Smp_007960   4-hydroxyphenylpyruvate dioxygenase
Schmidtea mediterranea mk4.019305.00   Putative 4-hydroxyphenylpyruvate dioxygenase
Schmidtea mediterranea mk4.001952.02   Putative 4-hydroxyphenylpyruvate dioxygenase
Schmidtea mediterranea mk4.009513.01   Putative 4-hydroxyphenylpyruvate dioxygenase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0288 0.2583 0.4066
0.0288 0.2583 0.4066
0.0288 0.2583 0.4066
0.0288 0.2583 0.4066
0.0288 0.2583 0.4066
0.0288 0.2583 0.4066
0.0288 0.2583 0.4066
0.0288 0.2583 0.4066
0.025 0.2545 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_007960 (Schistosoma mansoni), 4-hydroxyphenylpyruvate dioxygenase
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