Detailed view for Smp_125500

Basic information

TDR Targets ID: 292788
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 7.6634 | Length (AA): 498 | MW (Da): 56533 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07156   Prenylcysteine lyase
PF13450   NAD(P)-binding Rossmann-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016670   oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor  
GO:0001735   prenylcysteine oxidase activity  
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  
GO:0030328   prenylcysteine catabolic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 47 3c4n (A) 34 76 33.00 0 0.17 0.304253 0.89
4 494 6fw0 (A) 2 475 13.00 0 0.96 1.02694 0.63
6 50 5ts5 (A) 33 74 50.00 0.08 0.47 0.471561 0.9
9 480 3we0 (A) 48 540 15.00 0.000000000014 1 1.00779 0.58

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130625)

Species Accession Gene Product
Arabidopsis thaliana AT5G63910   farnesylcysteine lyase
Brugia malayi Bm1_36860   hypothetical protein
Dictyostelium discoideum DDB_G0287201   hypothetical protein
Echinococcus granulosus EgrG_000242100   prenylcysteine oxidase
Echinococcus multilocularis EmuJ_000242100   prenylcysteine oxidase
Homo sapiens ENSG00000145882   prenylcysteine oxidase 1 like
Homo sapiens ENSG00000116005   prenylcysteine oxidase 1
Loa Loa (eye worm) LOAG_06248   hypothetical protein
Mus musculus ENSMUSG00000029998   prenylcysteine oxidase 1
Mus musculus ENSMUSG00000024579   prenylcysteine oxidase 1 like
Oryza sativa 4337518   Os04g0692800
Onchocerca volvulus OVOC4531  
Schistosoma japonicum Sjp_0039870   ko:K05906 prenylcysteine oxidase [EC1.8.3.5], putative
Schistosoma japonicum Sjp_0039860   IPR010795,Prenylcysteine lyase,domain-containing
Schistosoma mansoni Smp_125500   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_125500 (Schistosoma mansoni), hypothetical protein
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