Detailed view for Smp_071020

Basic information

TDR Targets ID: 293241
Schistosoma mansoni, choline/ethanolaminephosphotransferase 1
Source Database / ID:  GeneDB

pI: 7.8472 | Length (AA): 403 | MW (Da): 44994 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 9

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01066   CDP-alcohol phosphatidyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016780   phosphotransferase activity, for other substituted phosphate groups  
GO:0016020   membrane  
GO:0008654   phospholipid biosynthetic process  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
179 230 3hzq (A) 42 90 33.00 0.7 0.09 0.0124323 3.48

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126828)

Species Accession Gene Product
Arabidopsis thaliana AT1G13560   aminoalcoholphosphotransferase 1
Arabidopsis thaliana AT3G25585   aminoalcoholphosphotransferase
Babesia bovis BBOV_IV011360   ethanolamine phosphatidyltransferase, putative
Brugia malayi Bm1_07055   CDP-alcohol phosphatidyltransferase family protein
Brugia malayi Bm1_02595   CDP-alcohol phosphatidyltransferase family protein
Candida albicans CaO19.11179   potential phosphatidyl transferase similar to S. cerevisiae EPT1 (YHR123W) involved in phosphatidylethanolamine biosynthesis
Candida albicans CaO19_3695   hypothetical protein
Candida albicans CaO19.3695   potential phosphatidyl transferase similar to S. cerevisiae EPT1 (YHR123W) involved in phosphatidylethanolamine biosynthesis
Caenorhabditis elegans CELE_F22E10.5   Protein CEPT-1, isoform B
Caenorhabditis elegans CELE_Y49A3A.1   Protein Y49A3A.1
Caenorhabditis elegans CELE_F54D7.2   Protein F54D7.2
Cryptosporidium hominis Chro.40314   ethanolaminephosphotransferase
Cryptosporidium parvum cgd4_2790   putative ethanolaminephosphotransferase (ETHPT) 9 transmembrane domain protein involved in lipid metabolism
Dictyostelium discoideum DDB_G0276763   CDP-alcohol phosphatidyltransferase
Dictyostelium discoideum DDB_G0278947   CDP-alcohol phosphatidyltransferase
Dictyostelium discoideum DDB_G0271794   CDP-alcohol phosphatidyltransferase
Drosophila melanogaster Dmel_CG33116   CG33116 gene product from transcript CG33116-RA
Drosophila melanogaster Dmel_CG6016   bb in a boxcar
Drosophila melanogaster Dmel_CG7149   CG7149 gene product from transcript CG7149-RB
Echinococcus granulosus EgrG_000251900   choline:ethanolaminephosphotransferase 1
Echinococcus granulosus EgrG_000452200   phosphatidyltransferase
Entamoeba histolytica EHI_067920   CDP-alcohol phosphatidyltransferase family protein
Entamoeba histolytica EHI_045570   CDP-alcohol phosphatidyltransferase family protein
Entamoeba histolytica EHI_182040   CDP-alcohol phosphatidyltransferase family protein
Echinococcus multilocularis EmuJ_000452200   phosphatidyltransferase
Echinococcus multilocularis EmuJ_000251900   choline:ethanolaminephosphotransferase 1
Homo sapiens ENSG00000138018   ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
Homo sapiens ENSG00000134255   choline/ethanolamine phosphotransferase 1
Leishmania braziliensis LbrM.35.6200   choline/ethanolamine phosphotransferase (CEPT), putative
Leishmania donovani LdBPK_030970.1   choline/ethanolamine phosphotransferase, putative
Leishmania donovani LdBPK_366160.1   choline/ethanolamine phosphotransferase, putative
Leishmania infantum LinJ.03.0970   aminoalcohol phosphotransferase, putative
Leishmania infantum LinJ.36.6160   choline/ethanolamine phosphotransferase (CEPT), putative
Leishmania major LmjF.36.5900   choline/ethanolamine phosphotransferase (CEPT), putative
Leishmania mexicana LmxM.03.0821   aminoalcohol phosphotransferase, putative
Leishmania mexicana LmxM.36.5900   aminoalcoholphosphotransferase, putative
Loa Loa (eye worm) LOAG_00490   CDP-alcohol phosphatidyltransferase
Loa Loa (eye worm) LOAG_06755   CDP-alcohol phosphatidyltransferase
Mus musculus ENSMUSG00000075703   ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
Mus musculus ENSMUSG00000040774   choline/ethanolaminephosphotransferase 1
Neospora caninum NCLIV_025720   ethanolaminephosphotransferase, putative
Neospora caninum NCLIV_029590   hypothetical protein
Oryza sativa 4340428   Os06g0204400
Oryza sativa 4328107   Os02g0119800
Onchocerca volvulus OVOC269   Ethanolaminephosphotransferase 1 homolog
Plasmodium berghei PBANKA_1127000   choline/ethanolaminephosphotransferase
Plasmodium falciparum PF3D7_0628300   choline/ethanolaminephosphotransferase, putative
Plasmodium knowlesi PKNH_1121500   choline/ethanolaminephosphotransferase, putative
Plasmodium vivax PVX_114515   ethanolaminephosphotransferase, putative
Plasmodium yoelii PY05544   LipB protein, putative
Saccharomyces cerevisiae YHR123W   bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase
Saccharomyces cerevisiae YNL130C   diacylglycerol cholinephosphotransferase
Schistosoma japonicum Sjp_0054500   ko:K00993 ethanolaminephosphotransferase [EC2.7.8.1], putative
Schistosoma japonicum Sjp_0215700   ko:K00994 diacylglycerol cholinephosphotransferase [EC2.7.8.2], putative
Schistosoma mansoni Smp_071020   choline/ethanolaminephosphotransferase 1
Schmidtea mediterranea mk4.012106.00   Choline/ethanolaminephosphotransferase 1
Schmidtea mediterranea mk4.012327.00   Choline/ethanolaminephosphotransferase 1
Schmidtea mediterranea mk4.008711.01   Choline/ethanolaminephosphotransferase 1
Schmidtea mediterranea mk4.001365.09   Ethanolaminephosphotransferase 1
Schmidtea mediterranea mk4.012052.00   Choline/ethanolaminephosphotransferase 1
Trypanosoma brucei gambiense Tbg972.10.10870   ethanolaminephosphotransferase, putative
Trypanosoma brucei Tb927.10.8900   choline/ethanolamine phosphotransferase (CEPT)
Trypanosoma congolense TcIL3000_10_7670   choline/ethanolamine phosphotransferase, putative
Trypanosoma cruzi TcCLB.509791.150   choline/ethanolamine phosphotransferase, putative
Trypanosoma cruzi TcCLB.508181.40   choline/ethanolamine phosphotransferase, putative
Trypanosoma cruzi TcCLB.508153.920   choline/ethanolamine phosphotransferase, putative
Trypanosoma cruzi TcCLB.511039.3   choline/ethanolamine phosphotransferase, putative
Toxoplasma gondii TGME49_261760   CDP-alcohol phosphatidyltransferase superfamily protein
Toxoplasma gondii TGME49_257510   CDP-alcohol phosphatidyltransferase superfamily protein
Treponema pallidum TP0671   sn-1,2-diacylglycerol cholinephosphotransferase
Theileria parva TP01_1171   hypothetical protein
Trichomonas vaginalis TVAG_055300   ethanolaminephosphotransferase, putative
Trichomonas vaginalis TVAG_173920   ethanolaminephosphotransferase, putative
Trichomonas vaginalis TVAG_236590   ethanolaminephosphotransferase, putative

Essentiality

Smp_071020 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.8900 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.8900 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.8900 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.8900 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y49A3A.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F54D7.2 Caenorhabditis elegans larval arrest wormbase
CELE_F54D7.2 Caenorhabditis elegans slow growth wormbase
PBANKA_1127000 Plasmodium berghei Essential plasmo
TGME49_257510 Toxoplasma gondii Essentiality uncertain sidik
TGME49_261760 Toxoplasma gondii Essentiality uncertain sidik
TGME49_257510 Toxoplasma gondii Probably essential sidik
TGME49_261760 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_071020 (Schistosoma mansoni), choline/ethanolaminephosphotransferase 1
Title for this comment
Comment