Detailed view for Smp_163660

Basic information

TDR Targets ID: 293321
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 5.0392 | Length (AA): 746 | MW (Da): 85750 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05186   Dpy-30 motif

Gene Ontology

Mouse over links to read term descriptions.
GO:0019205   nucleobase, nucleoside, nucleotide kinase activity  
GO:0006139   nucleobase, nucleoside, nucleotide and nucleic acid metabolic process  
GO:0005524   ATP binding  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Metabolic Pathways

Purine metabolism (KEGG)
Global map (KEGG)
Biosynthesis of antibiotics (KEGG)

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 271 3oh8 (A) 146 375 14.00 0.12 1 0.253109 0.67
314 381 1d2n (A) 508 575 38.00 0.41 0.32 0.416253 0.61
351 499 5g41 (A) 1 117 34.00 0.0021 1 0.367832 -0.24
594 732 4tql (A) 25 166 25.00 0.3 0.56 0.424427 -0.48
636 693 5wst (A) 874 931 38.00 0.8 0.07 0.635848 -2.07
638 734 2ocy (A) 32 147 37.00 0.05 0.17 0.246127 0.05
682 746 4rta (B) 24 96 34.00 0.00000073 0.15 0.499331 -0.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130764)

Species Accession Gene Product
Echinococcus granulosus EgrG_000519400   adenylate kinase 7
Echinococcus granulosus EgrG_000707300   adenylate kinase 7
Echinococcus multilocularis EmuJ_000519400   adenylate kinase 7
Echinococcus multilocularis EmuJ_000707300   adenylate kinase 7
Homo sapiens ENSG00000140057   adenylate kinase 7
Leishmania braziliensis LbrM.13.1120   hypothetical protein, conserved
Leishmania donovani LdBPK_131250.1   AAA domain/Dpy-30 motif containing protein, putative
Leishmania infantum LinJ.13.1250   hypothetical protein, conserved
Leishmania major LmjF.13.1350   hypothetical protein, conserved
Leishmania mexicana LmxM.13.1350   hypothetical protein, conserved
Mus musculus ENSMUSG00000041323   adenylate kinase 7
Neospora caninum NCLIV_030980   dpy-30 motif-containing protein, putative
Plasmodium berghei PBANKA_0404300   P-loop containing nucleoside triphosphate hydrolase, putative
Plasmodium falciparum PF3D7_0305800   P-loop containing nucleoside triphosphate hydrolase, putative
Plasmodium knowlesi PKNH_0836900   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_119415   hypothetical protein, conserved
Plasmodium yoelii PY05887   Plasmodium vivax PV1H14210_P
Schistosoma japonicum Sjp_0006240   ko:K00939 adenylate kinase [EC2.7.4.3], putative
Schistosoma mansoni Smp_163660   hypothetical protein
Schmidtea mediterranea mk4.001189.00   Adenylate kinase 7
Trypanosoma brucei gambiense Tbg972.11.3960   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.3500   Dpy-30 motif containing protein, putative
Trypanosoma congolense TcIL3000.11.3440   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507629.30   Dpy-30 motif containing protein, putative
Toxoplasma gondii TGME49_230460   Dpy-30 motif protein
Trichomonas vaginalis TVAG_282000   adenylate kinase, putative
Trichomonas vaginalis TVAG_372350   adenylate kinase, putative

Essentiality

Smp_163660 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.0990 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.0990 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.0990 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.0990 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0404300 Plasmodium berghei Dispensable plasmo
TGME49_230460 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_163660 (Schistosoma mansoni), hypothetical protein
Title for this comment
Comment