Detailed view for Smp_026930

Basic information

TDR Targets ID: 293448
Schistosoma mansoni, alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase
Source Database / ID:  GeneDB

pI: 8.9129 | Length (AA): 417 | MW (Da): 48841 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03071   GNT-I family

Gene Ontology

Mouse over links to read term descriptions.
GO:0000139   Golgi membrane  
GO:0008375   acetylglucosaminyltransferase activity  
GO:0006487   protein amino acid N-linked glycosylation  
GO:0006486   protein amino acid glycosylation  

Metabolic Pathways

N-Glycan biosynthesis (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
67 416 1fo8 (A) 107 446 46.00 0 1 1.42413 -1.08

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131824)

Species Accession Gene Product
Arabidopsis thaliana AT4G38240   alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Brugia malayi Bm1_21155   GNT-I family protein
Caenorhabditis elegans CELE_B0416.6   Protein GLY-13
Caenorhabditis elegans CELE_M01F1.1   Protein GLY-14
Dictyostelium discoideum DDB_G0288463   GlcNAc transferase
Drosophila melanogaster Dmel_CG13431   UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I
Echinococcus granulosus EgrG_000969800   alpha 13 mannosyl glycoprotein
Echinococcus multilocularis EmuJ_000969800   alpha 1,3 mannosyl glycoprotein
Homo sapiens ENSG00000131446   mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Loa Loa (eye worm) LOAG_06805   hypothetical protein
Loa Loa (eye worm) LOAG_08970   hypothetical protein
Mus musculus ENSMUSG00000020346   mannoside acetylglucosaminyltransferase 1
Oryza sativa 4331263   Os02g0832800
Schistosoma japonicum Sjp_0309500   ko:K00726 alpha-1,3-mannosyl-glycoprotein [EC2.4.1.101], putative
Schistosoma mansoni Smp_026930   alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase
Schmidtea mediterranea mk4.002507.00   Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Schmidtea mediterranea mk4.019600.00   Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Schmidtea mediterranea mk4.001840.01   Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Schmidtea mediterranea mk4.000577.05   Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Schmidtea mediterranea mk4.001840.00   Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Schmidtea mediterranea mk4.000877.04   Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_026930 (Schistosoma mansoni), alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase
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