Detailed view for Smp_040500

Basic information

TDR Targets ID: 293617
Schistosoma mansoni, fk506 binding protein
Source Database / ID:  GeneDB

pI: 6.9599 | Length (AA): 365 | MW (Da): 40434 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00254   FKBP-type peptidyl-prolyl cis-trans isomerase
PF14559   Tetratricopeptide repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005488   binding  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 166 2mph (A) 52 224 27.00 0 1 0.668536 0.34
7 165 1q6h (A) 78 223 30.00 0.22 0.66 0.598516 0.03
7 165 1q6h (A) 78 223 25.00 0 1 0.668316 -0.33
11 167 1jvw (A) 36 172 24.00 0.34 0.99 0.629037 -0.4
46 350 5omp (A) 130 424 19.00 0 1 1.02022 0.59
54 328 5mgx (E) 92 356 40.00 0 1 1.19212 -0.07
272 332 5djs (A) 4 64 20.00 0 0.98 0.598823 -1.64
279 336 2ho1 (A) 39 99 24.00 0.35 0.5 0.471504 -0.89

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133499)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG5482   CG5482 gene product from transcript CG5482-RC
Echinococcus granulosus EgrG_001036200   FK506 binding protein 8 38 kDa
Echinococcus multilocularis EmuJ_001036200   FK506 binding protein 8, 38 kDa
Homo sapiens ENSG00000105701   FK506 binding protein 8, 38kDa
Mus musculus ENSMUSG00000019428   FK506 binding protein 8
Schistosoma japonicum Sjp_0051840   ko:K09574 FK506-binding protein 8, putative
Schistosoma mansoni Smp_040500   fk506 binding protein
Schmidtea mediterranea mk4.000347.14   Peptidyl-prolyl cis-trans isomerase FKBP8

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Gallus gallus FK506 binding protein 12 108 aa 26.0% 96 aa Compounds References
Rattus norvegicus FK506-binding protein 1A 108 aa 29.2% 96 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_040500 (Schistosoma mansoni), fk506 binding protein
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