pI: 5.3191 |
Length (AA): 1172 |
MW (Da): 136281 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
92 | 361 | 4u06 (A) | 58 | 356 | 30.00 | 0.19 | 1 | 0.300675 | 1.25 |
254 | 485 | 4tql (A) | 13 | 236 | 22.00 | 0.034 | 0.96 | 0.536252 | -1.17 |
1098 | 1168 | 5j0k (A) | 4 | 73 | 20.00 | 0.56 | 0.08 | 0.41548 | -2.22 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126585)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G10180 | kinesin motor protein-related protein |
Arabidopsis thaliana | AT2G32240 | hypothetical protein |
Arabidopsis thaliana | AT5G41790 | COP1-interactive protein 1 |
Arabidopsis thaliana | AT5G40450 | hypothetical protein |
Brugia malayi | Bm1_45330 | GRIP domain containing protein |
Brugia malayi | Bm1_25800 | hypothetical protein |
Candida albicans | CaO19.2850 | large glutamic acid-rich orf |
Candida albicans | CaO19.10369 | large glutamic acid-rich orf |
Candida albicans | CaO19.1294 | weak similarity to internal and C terminal regions of general vesicular transport factor/Vesicle docking protein |
Candida albicans | CaO19.2629 | similar to S. cerevisiae USO1 (YDL058W) general vesicular transport factor/vesicle docking protein |
Caenorhabditis elegans | CELE_F59A2.6 | Protein F59A2.6 |
Caenorhabditis elegans | CELE_ZK973.6 | Protein ANC-1 |
Caenorhabditis elegans | CELE_F35D11.11 | Protein DYF-14, isoform D |
Caenorhabditis elegans | CELE_F59A2.2 | Protein F59A2.2, isoform A |
Cryptosporidium hominis | Chro.20077 | hypothetical protein |
Cryptosporidium hominis | Chro.40034 | myosin heavy chain |
Cryptosporidium hominis | Chro.40063 | hypothetical protein |
Cryptosporidium parvum | cgd4_200 | large low complexity coiled coil protien with large repeat region |
Cryptosporidium parvum | cgd4_480 | hypothetical protein |
Cryptosporidium parvum | cgd2_680 | hypothetical protein |
Dictyostelium discoideum | DDB_G0271334 | C2 calcium/lipid-binding region-containing protein |
Dictyostelium discoideum | DDB_G0281503 | hypothetical protein |
Dictyostelium discoideum | DDB_G0289719 | hypothetical protein |
Dictyostelium discoideum | DDB_G0290503 | hypothetical protein |
Dictyostelium discoideum | DDB_G0272368 | hypothetical protein |
Dictyostelium discoideum | DDB_G0285101 | kinesin family member 4 |
Dictyostelium discoideum | DDB_G0288285 | myb domain-containing protein |
Dictyostelium discoideum | DDB_G0269048 | hypothetical protein |
Drosophila melanogaster | Dmel_CG13648 | tenectin |
Drosophila melanogaster | Dmel_CG6450 | lava lamp |
Drosophila melanogaster | Dmel_CG6392 | CENP-meta |
Drosophila melanogaster | Dmel_CG44162 | Stretchin-Mlck |
Drosophila melanogaster | Dmel_CG33694 | CENP-ana |
Drosophila melanogaster | Dmel_CG3493 | Golgin-245 ortholog (H. sapiens) |
Drosophila melanogaster | Dmel_CG12047 | mushroom body defect |
Escherichia coli | b0924 | chromosome condensin MukBEF, ATPase and DNA-binding subunit |
Echinococcus granulosus | EgrG_000453500 | sporulation specific protein 15 |
Entamoeba histolytica | EHI_072050 | Viral A-type inclusion protein repeat, putative |
Echinococcus multilocularis | EmuJ_000453500 | conserved hypothetical protein |
Giardia lamblia | GL50803_6082 | Hypothetical protein |
Giardia lamblia | GL50803_14584 | Hypothetical protein |
Giardia lamblia | GL50803_13475 | Axoneme-associated protein GASP-180 |
Giardia lamblia | GL50803_15995 | Nucleotide-binding head-stalk protein, putative |
Giardia lamblia | GL50803_113677 | Coiled-coil protein |
Homo sapiens | ENSG00000173230 | golgin B1 |
Homo sapiens | ENSG00000138778 | centromere protein E, 312kDa |
Homo sapiens | ENSG00000117724 | centromere protein F, 350/400kDa |
Homo sapiens | ENSG00000144674 | golgin A4 |
Leishmania braziliensis | LbrM.20.2090 | hypothetical protein, unknown function |
Leishmania braziliensis | LbrM.16.1510 | kinesin, putative |
Leishmania braziliensis | LbrM.14.1120 | kinesin K39, putative |
Leishmania braziliensis | LbrM.14.1100 | kinesin K39, putative |
Leishmania braziliensis | LbrM.14.1310 | kinesin K39, putative |
Leishmania braziliensis | LbrM.20.2070 | hypothetical protein, unknown function |
Leishmania braziliensis | LbrM.20.4280 | hypothetical protein, conserved |
Leishmania braziliensis | LbrM.16.1520 | kinesin, putative |
Leishmania braziliensis | LbrM.20.0620 | hypothetical protein, conserved |
Leishmania braziliensis | LbrM.20.2080 | hypothetical protein, unknown function |
Leishmania braziliensis | LbrM.20.2100 | hypothetical protein, unknown function |
Leishmania braziliensis | LbrM.16.1530 | kinesin, putative |
Leishmania braziliensis | LbrM.22.1200 | hypothetical protein, unknown function |
Leishmania donovani | LdBPK_340710.1 | flagellar attachment zone protein, putative |
Leishmania donovani | LdBPK_342360.1 | flagellar attachment zone protein, putative |
Leishmania donovani | LdBPK_340720.1 | flagellar attachment zone protein, putative |
Leishmania donovani | LdBPK_221150.1 | hypothetical protein, unknown function |
Leishmania infantum | LinJ.16.1570 | kinesin, putative |
Leishmania infantum | LinJ.34.0710 | hypothetical protein, conserved |
Leishmania infantum | LinJ.34.2350 | hypothetical protein, unknown function |
Leishmania infantum | LinJ.16.1550 | kinesin, putative |
Leishmania infantum | LinJ.34.0720 | hypothetical protein, conserved |
Leishmania infantum | LinJ.22.1150 | hypothetical protein, unknown function |
Leishmania infantum | LinJ.14.1600 | kinesin K39, putative |
Leishmania infantum | LinJ.14.1190 | kinesin K39, putative |
Leishmania infantum | LinJ.22.1160 | hypothetical protein, unknown function |
Leishmania infantum | LinJ.14.1180 | kinesin K39, putative |
Leishmania infantum | LinJ.34.2360 | hypothetical protein, unknown function |
Leishmania major | LmjF.16.1460 | kinesin, putative |
Leishmania major | LmjF.14.1110 | kinesin K39, putative |
Leishmania major | LmjF.34.2530 | hypothetical protein, unknown function |
Leishmania major | LmjF.16.1470 | kinesin, putative |
Leishmania major | LmjF.34.0690 | hypothetical protein, conserved |
Leishmania major | LmjF.14.1100 | kinesin K39, putative |
Leishmania major | LmjF.14.1120 | kinesin K39, putative |
Leishmania mexicana | LmxM.33.0690 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.16.1460cpartial | |
Leishmania mexicana | LmxM.14.1120 | kinesin K39, putative |
Leishmania mexicana | LmxM.16.1460 | kinesin, putative |
Leishmania mexicana | LmxM.14.1100 | kinesin K39, putative |
Leishmania mexicana | LmxM.22.1320 | hypothetical protein, unknown function |
Leishmania mexicana | LmxM.14.1120a | |
Leishmania mexicana | LmxM.14.1100partial | |
Leishmania mexicana | LmxM.14.1110 | kinesin K39, putative |
Leishmania mexicana | LmxM.33.2530 | hypothetical protein, unknown function |
Leishmania mexicana | LmxM.16.1460a | |
Leishmania mexicana | LmxM.16.1470 | kinesin, putative |
Loa Loa (eye worm) | LOAG_10386 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15148 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08963 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08765 | hypothetical protein |
Loa Loa (eye worm) | LOAG_09758 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08962 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00606 | hypothetical protein |
Loa Loa (eye worm) | LOAG_09757 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14646 | hypothetical protein |
Mus musculus | ENSMUSG00000026605 | centromere protein F |
Mus musculus | ENSMUSG00000038708 | golgi autoantigen, golgin subfamily a, 4 |
Mus musculus | 102634004 | predicted gene, 31694 |
Mus musculus | ENSMUSG00000045328 | centromere protein E |
Mus musculus | 102633307 | predicted gene, 31166 |
Mus musculus | ENSMUSG00000090546 | cerebellar degeneration related antigen 1 |
Mus musculus | ENSMUSG00000034243 | golgi autoantigen, golgin subfamily b, macrogolgin 1 |
Neospora caninum | NCLIV_012990 | hypothetical protein |
Neospora caninum | NCLIV_019030 | viral A-type inclusion protein repeat family, putative |
Oryza sativa | 4340605 | Os06g0237300 |
Oryza sativa | 4331702 | Os03g0161100 |
Onchocerca volvulus | OVOC8420 |
|
Onchocerca volvulus | OVOC2355 |
|
Plasmodium berghei | PBANKA_0313400 | autophagy-related protein 11, putative |
Plasmodium berghei | PBANKA_0110500 | leucine-rich repeat protein |
Plasmodium berghei | PBANKA_0301000 | repetitive organellar protein, putative |
Plasmodium berghei | PBANKA_1306500 | TRAP-like protein |
Plasmodium berghei | PBANKA_1454200 | conserved Plasmodium protein, unknown function |
Plasmodium berghei | PBANKA_1220800 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_1239800 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_0710200 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_0216700 | autophagy-related protein 11, putative |
Plasmodium falciparum | PF3D7_0612200 | leucine-rich repeat protein |
Plasmodium falciparum | PF3D7_1038400 | gametocyte-specific protein |
Plasmodium falciparum | PF3D7_1149000 | antigen 332, DBL-like protein |
Plasmodium falciparum | PF3D7_0500800 | mature parasite-infected erythrocyte surface antigen |
Plasmodium falciparum | PF3D7_0203000 | repetitive organellar protein, putative |
Plasmodium knowlesi | PKNH_1433400 | conserved Plasmodium protein, unknown function |
Plasmodium knowlesi | PKNH_0418100 | repetitive organellar protein, putative |
Plasmodium knowlesi | PKNH_0404200 | autophagy-related protein 11, putative |
Plasmodium knowlesi | PKNH_1137800 | leucine-rich repeat protein |
Plasmodium knowlesi | PKNH_1459900 | conserved Plasmodium protein, unknown function |
Plasmodium knowlesi | PKNH_0108900 | conserved Plasmodium protein, unknown function |
Plasmodium vivax | PVX_100940 | hypothetical protein, conserved |
Plasmodium vivax | PVX_003585 | repetitive organellar protein, putative |
Plasmodium vivax | PVX_002550 | hypothetical protein, conserved |
Plasmodium vivax | PVX_113755 | hypothetical protein, conserved |
Plasmodium vivax | PVX_002705 | autophagy-related protein 11, putative |
Plasmodium vivax | PVX_088045 | hypothetical protein, conserved |
Plasmodium vivax | PVX_101530 | Plasmodium exported protein, unknown function |
Plasmodium yoelii | PY03350 | erythrocyte membrane-associated giant protein antigen 332 |
Plasmodium yoelii | PY05279 | hypothetical protein |
Plasmodium yoelii | PY00447 | repeat organellar protein-related |
Plasmodium yoelii | PY04986 | 250-270 copies of a 13 AA repeat, NSSTPITSSSIL |
Plasmodium yoelii | PY02913 | hypothetical protein |
Plasmodium yoelii | PY02217 | hypothetical protein |
Plasmodium yoelii | PY02271 | hypothetical protein |
Plasmodium yoelii | PY03361 | hypothetical protein |
Plasmodium yoelii | PY04214 | repeat organellar protein-related |
Plasmodium yoelii | PY04691 | R27-2 protein |
Saccharomyces cerevisiae | YDL058W | Uso1p |
Saccharomyces cerevisiae | YKR095W | Mlp1p |
Saccharomyces cerevisiae | YIL149C | Mlp2p |
Schistosoma japonicum | Sjp_0123850 | expressed protein |
Schistosoma japonicum | Sjp_0312970 | expressed protein |
Schistosoma japonicum | Sjp_0126320 | IPR009053,Prefoldin,domain-containing |
Schistosoma japonicum | Sjp_0051210 | IPR000237,GRIP,domain-containing |
Schistosoma japonicum | Sjp_0110210 | IPR009053,Prefoldin;IPR010978,tRNA-binding arm,domain-containing |
Schistosoma japonicum | Sjp_0305620 | expressed protein |
Schistosoma japonicum | Sjp_0206790 | IPR005479,Carbamoyl-phosphate synthase L chain, ATP-binding,domain-containing |
Schistosoma mansoni | Smp_023940 | hypothetical protein |
Schistosoma mansoni | Smp_171970 | hypothetical protein |
Schmidtea mediterranea | mk4.001715.04 | |
Schmidtea mediterranea | mk4.009521.00 | |
Schmidtea mediterranea | mk4.015478.00 | |
Schmidtea mediterranea | mk4.025160.03 | |
Schmidtea mediterranea | mk4.046343.00 | |
Schmidtea mediterranea | mk4.012180.01 | |
Schmidtea mediterranea | mk4.025160.02 | |
Schmidtea mediterranea | mk4.012757.00 | |
Schmidtea mediterranea | mk4.005383.04 | |
Schmidtea mediterranea | mk4.016257.00 | |
Schmidtea mediterranea | mk4.005332.01 | |
Schmidtea mediterranea | mk4.002942.05 | |
Schmidtea mediterranea | mk4.001963.00 | |
Schmidtea mediterranea | mk4.028588.00 | |
Schmidtea mediterranea | mk4.025889.00 | |
Schmidtea mediterranea | mk4.018769.00 | |
Trypanosoma brucei gambiense | Tbg972.7.4290 | kinesin K39, putative |
Trypanosoma brucei gambiense | Tbg972.4.3690 | flagellar attachment zone protein, putative |
Trypanosoma brucei gambiense | Tbg972.1.950 | T. brucei spp.-specific protein,hypothetical protein |
Trypanosoma brucei gambiense | Tbg972.7.3660 | hypothetical protein, conserved |
Trypanosoma brucei gambiense | Tbg972.8.4770 | |
Trypanosoma brucei gambiense | Tbg972.8.4775 | |
Trypanosoma brucei gambiense | Tbg972.7.4260 | |
Trypanosoma brucei | Tb11.v5.0493 | kinesin K39, putative |
Trypanosoma brucei | Tb927.1.1740 | Microtubule-associated protein futsch, putative |
Trypanosoma brucei | Tb11.v5.0410 | antigenic protein, conserved |
Trypanosoma brucei | Tb927.7.3330 | Flagellar attachment zone protein 10 |
Trypanosoma brucei | Tb927.7.3830 | kinesin K39, putative |
Trypanosoma brucei | Tb927.4.3740 | flagellar attachment zone protein 1 |
Trypanosoma brucei | Tb927.8.4950 | kinesin, putative |
Trypanosoma congolense | TcIL3000_7_3090 | kinesin K39, putative |
Trypanosoma congolense | TcIL3000_4_3240 | Flagellar attachment zone protein 1, putative |
Trypanosoma congolense | TcIL3000_8_4720 | kinesin, putative |
Trypanosoma cruzi | TcCLB.506491.20 | myosin heavy chain, putative |
Trypanosoma cruzi | TcCLB.511823.14 | Flagellar attachment zone protein 10 |
Trypanosoma cruzi | TcCLB.504227.5 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.506439.9 | myosin heavy chain, putative |
Trypanosoma cruzi | TcCLB.510247.10 | R27-2 protein, putative |
Trypanosoma cruzi | TcCLB.511821.179 | Flagellar attachment zone protein 10 |
Trypanosoma cruzi | TcCLB.511215.70 | kinesin, putative |
Trypanosoma cruzi | TcCLB.509631.140 | Flagellar attachment zone protein 1, putative |
Trypanosoma cruzi | TcCLB.506201.170 | Flagellar attachment zone protein 1, putative |
Toxoplasma gondii | TGME49_212880 | surface antigen repeat-containing protein |
Toxoplasma gondii | TGME49_244470 | hypothetical protein |
Toxoplasma gondii | TGME49_252880 | hypothetical protein |
Treponema pallidum | TP0627 | exonuclease (sbcC) |
Theileria parva | TP01_0736 | hypothetical protein |
Theileria parva | TP01_0575 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_458090 | centromeric protein E, putative |
Trichomonas vaginalis | TVAG_007510 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_238370 | sporulation-specific protein, putative |
Trichomonas vaginalis | TVAG_010490 | centromeric protein E, putative |
Trichomonas vaginalis | TVAG_244940 | centromeric protein E, putative |
Trichomonas vaginalis | TVAG_012450 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_087170 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_216960 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_474650 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_399490 | Microtubule-associated protein futsch, putative |
Trichomonas vaginalis | TVAG_190140 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_193720 | centromeric protein E, putative |
Trichomonas vaginalis | TVAG_021170 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_410100 | centromeric protein E, putative |
Trichomonas vaginalis | TVAG_339270 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_193760 | nuclear anchorage protein, putative |
Trichomonas vaginalis | TVAG_268110 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_139760 | Intracellular protein transport protein USO1, putative |
Trichomonas vaginalis | TVAG_538490 | peptidoglycan DL-endopeptidase cwlO precursor, putative |
Trichomonas vaginalis | TVAG_193740 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_193730 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_480920 | trichohyalin, putative |
Trichomonas vaginalis | TVAG_031940 | trichohyalin, putative |
Trichomonas vaginalis | TVAG_198570 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_355490 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_154410 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_407710 | trichohyalin, putative |
Trichomonas vaginalis | TVAG_579680 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_387410 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_110290 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_007500 | centromeric protein E, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0274 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.3330 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.3330 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.3330 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.3330 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.7.3830 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.3830 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.3830 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.7.3830 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.4.3740 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.3740 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.3740 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.4.3740 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.8.4950 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.4950 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.4950 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.4950 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.1.1740 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.1740 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.1740 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.1.1740 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0924 | Escherichia coli | essential | goodall |
CELE_ZK973.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZK973.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_ZK973.6 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_ZK973.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F35D11.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
YDL058W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0301000 | Plasmodium berghei | Dispensable | plasmo |
PBANKA_0313400 | Plasmodium berghei | Slow | plasmo |
PBANKA_1454200 | Plasmodium berghei | Essential | plasmo |
TGME49_244470 | Toxoplasma gondii | Probably essential | sidik |
TGME49_252880 | Toxoplasma gondii | Probably essential | sidik |
TGME49_212880 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | centromere protein E, 312kDa | Compounds | References |