Detailed view for Smp_160850

Basic information

TDR Targets ID: 293797
Schistosoma mansoni, Tpr
Source Database / ID:  GeneDB

pI: 4.7685 | Length (AA): 2458 | MW (Da): 276170 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07926   TPR/MLP1/MLP2-like protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0005874   microtubule  
GO:0005643   nuclear pore  
GO:0051082   unfolded protein binding  
GO:0007021   tubulin folding  
GO:0006606   protein import into nucleus  

Metabolic Pathways

RNA transport (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
33 1268 5kk5 (A) 7 1283 15.00 0 1 0.273148 1.44
290 449 2efr (A) 148 301 30.00 0.16 0.02 0.157294 0.6
826 1012 4uos (A) 2 184 22.00 0.0099 1 0.559278 -2.13

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129652)

Species Accession Gene Product
Arabidopsis thaliana AT1G79280   nuclear pore anchor
Brugia malayi Bm1_11925   Viral A-type inclusion protein repeat containing protein
Candida albicans CaO19.4683   myosin-like protein
Candida albicans CaO19.12152   myosin-like protein
Caenorhabditis elegans CELE_R07G3.3   Protein NPP-21, isoform B
Dictyostelium discoideum DDB_G0288073   hypothetical protein
Drosophila melanogaster Dmel_CG8274   Megator
Echinococcus granulosus EgrG_000102000   nucleoprotein TPR
Echinococcus multilocularis EmuJ_000102000   nucleoprotein TPR
Homo sapiens ENSG00000047410   translocated promoter region, nuclear basket protein
Loa Loa (eye worm) LOAG_06949   hypothetical protein
Loa Loa (eye worm) LOAG_08920   viral A-type inclusion protein repeat containing protein
Mus musculus ENSMUSG00000006005   translocated promoter region, nuclear basket protein
Neospora caninum NCLIV_008850   hypothetical protein, conserved
Oryza sativa 4330687   Os02g0741500
Onchocerca volvulus OVOC10101  
Schistosoma japonicum Sjp_0033840   ko:K09291 nucleoprotein TPR, putative
Schistosoma japonicum Sjp_0088580   ko:K09291 nucleoprotein TPR, putative
Schistosoma mansoni Smp_160850   Tpr
Schmidtea mediterranea mk4.002240.06   Nucleoprotein TPR
Schmidtea mediterranea mk4.002240.07   Nucleoprotein TPR
Toxoplasma gondii TGME49_254570   hypothetical protein

Essentiality

Smp_160850 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R07G3.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_R07G3.3 Caenorhabditis elegans larval arrest wormbase
TGME49_254570 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_160850 (Schistosoma mansoni), Tpr
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