Detailed view for Smp_166830

Basic information

TDR Targets ID: 293856
Schistosoma mansoni, methyltransferase-related
Source Database / ID:  GeneDB

pI: 8.9212 | Length (AA): 285 | MW (Da): 32356 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08241   Methyltransferase domain
PF12589   Methyltransferase involved in Williams-Beuren syndrome

Gene Ontology

Mouse over links to read term descriptions.
GO:0070476   GO:rRNA (guanine-N7)-methylation  

GO:0016435   rRNA (guanine) methyltransferase activity  
GO:0008168   methyltransferase activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 284 6ecu (A) 981 1264 15.00 0 1 1.07828 0.12
22 213 4qtu (B) 12 202 54.00 0 1 1.42708 -1.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128094)

Species Accession Gene Product
Arabidopsis thaliana AT5G57280   methyltransferase-like protein
Babesia bovis BBOV_III004000   conserved hypothetical protein
Brugia malayi Bm1_15635   hypothetical protein
Candida albicans CaO19.9522   similar to rat methylglycine transferase
Candida albicans CaO19.1966   similar to rat methylglycine transferase
Caenorhabditis elegans CELE_C27F2.4   Protein C27F2.4
Cryptosporidium hominis Chro.10303   S-adenosylmethionine-dependentmethyltransferase
Cryptosporidium parvum cgd1_2680   HUSSY-3 like methyltransferase
Dictyostelium discoideum DDB_G0269722   hypothetical protein
Drosophila melanogaster Dmel_CG10903   CG10903 gene product from transcript CG10903-RB
Echinococcus granulosus EgrG_000721700   williams beuren syndrome chromosome region 22
Entamoeba histolytica EHI_029570   methyltransferase, putative
Echinococcus multilocularis EmuJ_000721700   williams beuren syndrome chromosome region 22
Giardia lamblia GL50803_21512   S-adenosylmethionine-dependent methyltransferase, putative
Homo sapiens ENSG00000071462   Williams Beuren syndrome chromosome region 22
Leishmania braziliensis LbrM.20.2300   methyltransferase-like protein
Leishmania donovani LdBPK_342580.1   methyltransferase-like protein
Leishmania infantum LinJ.34.2580   methyltransferase-like protein
Leishmania major LmjF.34.2750   methyltransferase-like protein
Leishmania mexicana LmxM.33.2750   methyltransferase-like protein
Loa Loa (eye worm) LOAG_05054   methyltransferase
Mus musculus ENSMUSG00000005378   Williams Beuren syndrome chromosome region 22
Neospora caninum NCLIV_026450   hypothetical protein, conserved
Oryza sativa 4331056   Os02g0804300
Onchocerca volvulus OVOC9165   Ribosome biogenesis methyltransferase WBSCR22 homolog
Plasmodium berghei PBANKA_1237000   18S rRNA (guanine-N(7))-methyltransferase, putative
Plasmodium falciparum PF3D7_0522300   18S rRNA (guanine-N(7))-methyltransferase, putative
Plasmodium knowlesi PKNH_1010600   18S rRNA (guanine-N(7))-methyltransferase, putative
Plasmodium vivax PVX_080135   S-adenosylmethionine-dependent methyltransferase, putative
Saccharomyces cerevisiae YCR047C   Bud23p
Schistosoma japonicum Sjp_0035040   ko:K00599 Williams Beuren syndrome chromosome region 22 [EC:2.1.1.-], putative
Schistosoma mansoni Smp_166830   methyltransferase-related
Trypanosoma brucei gambiense Tbg972.4.1810   hypothetical protein, conserved
Trypanosoma brucei Tb927.4.1900   Methyltransferase domain/Methyltransferase involved in Williams-Beuren syndrome, putative
Trypanosoma congolense TcIL3000_0_39410   Methyltransferase domain/Methyltransferase involved in Williams-Beuren syndrome, putative
Trypanosoma congolense TcIL3000_4_1580   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.503923.30   Methyltransferase domain/Methyltransferase involved in Williams-Beuren syndrome, putative
Trypanosoma cruzi TcCLB.508583.10   Methyltransferase domain/Methyltransferase involved in Williams-Beuren syndrome, putative
Toxoplasma gondii TGME49_260610   methyltransferase
Theileria parva TP03_0020   methyltransferase, putative
Trichomonas vaginalis TVAG_021330   conserved hypothetical protein

Essentiality

Smp_166830 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.1900 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.1900 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.4.1900 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.1900 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C27F2.4 Caenorhabditis elegans slow growth wormbase
TGME49_260610 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_166830 (Schistosoma mansoni), methyltransferase-related
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