Detailed view for Smp_140770
Basic information
Schistosoma mansoni, protein phosphatase-7
Source Database / ID: GeneDB
pI: 6.2812 |
Length (AA): 628 |
MW (Da): 72133 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0030145 manganese ion binding
GO:0016787 hydrolase activity
GO:0005509 calcium ion binding
GO:0005506 iron ion binding
GO:0004721 phosphoprotein phosphatase activity
Metabolic Pathways
Structural information
Modbase 3D models:
There are 11 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 108 | 448 | 1aui (A) | 21 | 352 | 20.00 | 0.00049 | 1 | 0.849794 | -0.6 |
| 111 | 413 | 5jjt (A) | 158 | 449 | 41.00 | 0 | 1 | 1.03788 | -1.06 |
| 129 | 295 | 5jpe (A) | 177 | 343 | 29.00 | 0.029 | 1 | 0.708724 | -1.36 |
| 460 | 628 | 4n5x (A) | 22 | 176 | 19.00 | 0 | 1 | 0.453808 | -0.71 |
| 461 | 609 | 2hps (A) | 15 | 165 | 22.00 | 0 | 1 | 0.570961 | -0.85 |
| 462 | 609 | 1s6i (A) | 12 | 143 | 33.00 | 0.00011 | 0.53 | 0.415069 | 0.63 |
| 522 | 609 | 5ve9 (A) | 7022 | 7107 | 23.00 | 0.019 | 0.69 | 0.521927 | -1.26 |
| 534 | 575 | 3nyv (A) | 465 | 506 | 21.00 | 0 | 0.6 | 0.410579 | -0.9 |
| 544 | 605 | 1k9u (A) | 3 | 61 | 47.00 | 0.00011 | 0.65 | 0.513126 | 0.6 |
| 546 | 608 | 2pmy (A) | 13 | 71 | 36.00 | 0.022 | 0.9 | 0.543718 | -0.64 |
| 546 | 612 | 2m97 (A) | 5 | 69 | 38.00 | 0.058 | 1 | 0.738088 | -1.92 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_131440)
| Species | Accession | Gene Product |
|---|---|---|
| Brugia malayi | Bm1_03005 | Ser/Thr protein phosphatase family protein |
| Caenorhabditis elegans | CELE_F23H11.8 | Protein PEF-1, isoform C |
| Drosophila melanogaster | Dmel_CG44746 | retinal degeneration C |
| Echinococcus granulosus | EgrG_000211200 | serine:threonine protein phosphatase with |
| Entamoeba histolytica | EHI_117570 | serine/threonine protein phosphatase, putative |
| Echinococcus multilocularis | EmuJ_000211200 | serine:threonine protein phosphatase with |
| Homo sapiens | ENSG00000156194 | protein phosphatase, EF-hand calcium binding domain 2 |
| Homo sapiens | ENSG00000086717 | protein phosphatase, EF-hand calcium binding domain 1 |
| Loa Loa (eye worm) | LOAG_14099 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_06253 | phosphatase with ef hands protein 1 |
| Mus musculus | ENSMUSG00000062168 | protein phosphatase with EF hand calcium-binding domain 1 |
| Mus musculus | ENSMUSG00000029410 | protein phosphatase, EF hand calcium-binding domain 2 |
| Schistosoma japonicum | Sjp_0005750 | ko:K01090 protein phosphatase [EC3.1.3.16], putative |
| Schistosoma japonicum | Sjp_0095750 | Serine/threonine-protein phosphatase with EF-hands 1, putative |
| Schistosoma mansoni | Smp_140770 | protein phosphatase-7 |
| Schmidtea mediterranea | mk4.005482.02 | |
| Schmidtea mediterranea | mk4.013371.00 | Serine/threonine-protein phosphatase rdgC |
| Schmidtea mediterranea | mk4.021878.01 | |
| Schmidtea mediterranea | mk4.021878.02 | Serine/threonine-protein phosphatase rdgC |
| Schmidtea mediterranea | mk4.023905.00 | Serine/threonine-protein phosphatase rdgC |
| Schmidtea mediterranea | mk4.001594.00 | |
| Schmidtea mediterranea | mk4.010835.03 | Serine/threonine-protein phosphatase rdgC |
| Schmidtea mediterranea | mk4.013959.01 | |
| Schmidtea mediterranea | mk4.013959.00 | Serine/threonine-protein phosphatase rdgC |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
By sequence similarity to non orthologous druggable targets
| Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
|---|---|---|---|---|---|---|
| Bos taurus | Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform | 309 aa | 34.1% | 267 aa | Compounds | References |
| Oryctolagus cuniculus | Serine/threonine protein phosphatase PP1-alpha catalytic subunit | 330 aa | 33.3% | 288 aa | Compounds | References |
Obtained from network model
Assayability
Assay information
Reagent availability
Bibliographic References