Detailed view for Smp_161940

Basic information

TDR Targets ID: 294072
Schistosoma mansoni, cytochrome oxidase biogenesis protein (oxa1 mitochondrial)
Source Database / ID:  GeneDB

pI: 9.6272 | Length (AA): 304 | MW (Da): 34065 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02096   60Kd inner membrane protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0032977   membrane insertase activity  
GO:0016021   integral to membrane  
GO:0051205   protein insertion into membrane  

Metabolic Pathways

Protein export (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
88 293 3wo7 (A) 27 239 20.00 0 0.27 0.721332 0.77
189 266 3tds (E) 15 85 32.00 0.4 0.06 0.406779 0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128453)

Species Accession Gene Product
Arabidopsis thaliana AT2G46470   inner membrane OXA1-like protein
Arabidopsis thaliana AT5G62050   mitochondrial inner membrane protein OXA1
Babesia bovis BBOV_IV002440   cytochrome oxidase biogenesis protein 1-1 (OXA1), putative
Brugia malayi Bm1_54550   60Kd inner membrane protein
Brugia malayi Bm1_54555   60Kd inner membrane protein
Candida albicans CaO19_6565   hypothetical protein
Candida albicans CaO19.6565   assembly of cytochrome oxidase, ATP synthase
Candida albicans CaO19.13918   assembly of cytochrome oxidase, ATP synthase
Caenorhabditis elegans CELE_C01A2.3   Protein C01A2.3
Dictyostelium discoideum DDB_G0284883   hypothetical protein
Dictyostelium discoideum DDB_G0281171   hypothetical protein
Drosophila melanogaster Dmel_CG6404   CG6404 gene product from transcript CG6404-RA
Echinococcus granulosus EgrG_000251800   cytochrome oxidase biogenesis protein
Echinococcus multilocularis EmuJ_000251800   cytochrome oxidase biogenesis protein
Homo sapiens ENSG00000155463   oxidase (cytochrome c) assembly 1-like
Leishmania braziliensis LbrM.11.0980   hypothetical protein, conserved
Leishmania donovani LdBPK_111170.1   60Kd inner membrane protein, putative
Leishmania infantum LinJ.11.1170   hypothetical protein, conserved
Leishmania major LmjF.11.1180   hypothetical protein, conserved
Leishmania mexicana LmxM.11.1180   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_04050   60Kd inner membrane protein
Loa Loa (eye worm) LOAG_04051   hypothetical protein
Mus musculus ENSMUSG00000000959   oxidase assembly 1-like
Oryza sativa 4349143   Os10g0521300
Oryza sativa 4331399   Os03g0116000
Onchocerca volvulus OVOC227   Mitochondrial inner membrane protein homolog
Plasmodium berghei PBANKA_0702300   mitochondrial inner membrane protein OXA1, putative
Plasmodium falciparum PF3D7_0828400   mitochondrial inner membrane protein OXA1, putative
Plasmodium knowlesi PKNH_1322500   mitochondrial inner membrane protein OXA1, putative
Plasmodium vivax PVX_088935   mitochondrial inner membrane protein OXA1, putative
Plasmodium yoelii PY05780   hypothetical protein
Saccharomyces cerevisiae YER154W   Oxa1p
Schistosoma japonicum Sjp_0215380   ko:K03217 preprotein translocase YidC subunit, putative
Schistosoma mansoni Smp_161940   cytochrome oxidase biogenesis protein (oxa1 mitochondrial)
Schmidtea mediterranea mk4.005590.01   Mitochondrial inner membrane protein OXA1L
Schmidtea mediterranea mk4.003072.00   Mitochondrial inner membrane protein OXA1L
Schmidtea mediterranea mk4.004522.01   Mitochondrial inner membrane protein OXA1L
Schmidtea mediterranea mk4.004522.02   Mitochondrial inner membrane protein OXA1L
Schmidtea mediterranea mk4.003739.02   Putative cytochrome oxidase biogenesis protein
Schmidtea mediterranea mk4.015153.01   Mitochondrial inner membrane protein OXA1L
Trypanosoma brucei gambiense Tbg972.11.6930   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.6150   60Kd inner membrane protein, putative
Trypanosoma congolense TcIL3000.11.6680   60Kd inner membrane protein, putative
Trypanosoma cruzi TcCLB.508041.50   60Kd inner membrane protein, putative
Trypanosoma cruzi TcCLB.506297.310   60Kd inner membrane protein, putative
Theileria parva TP03_0408   hypothetical protein

Essentiality

Smp_161940 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.4020 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.4020 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.4020 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.4020 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C01A2.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_C01A2.3 Caenorhabditis elegans larval arrest wormbase
CELE_C01A2.3 Caenorhabditis elegans slow growth wormbase
PBANKA_0702300 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_161940 (Schistosoma mansoni), cytochrome oxidase biogenesis protein (oxa1 mitochondrial)
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