Detailed view for Smp_171700

Basic information

TDR Targets ID: 294109
Schistosoma mansoni, myst histone acetyltransferase
Source Database / ID:  GeneDB

pI: 8.0727 | Length (AA): 404 | MW (Da): 46946 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01853   MOZ/SAS family

Gene Ontology

Mouse over links to read term descriptions.
GO:0035267   NuA4 histone acetyltransferase complex  
GO:0016573   histone acetylation  
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005634   nucleus  
GO:0004402   histone acetyltransferase activity  
GO:0045449   regulation of transcription  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 52 3e9g (A) 77 127 10.00 0.00042 0 0.251238 -0.45
94 394 5wci (A) 165 447 45.00 0 1 1.26745 -0.64
113 394 2ou2 (A) 178 452 51.00 0 1 1.19442 -0.48
115 394 5gk9 (A) 337 605 48.00 0 1 1.26747 -0.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_140862)

Species Accession Gene Product
Echinococcus granulosus EgrG_000633200   histone acetyltransferase MYST2
Echinococcus multilocularis EmuJ_000633200   histone acetyltransferase MYST2
Leishmania braziliensis LbrM.35.7380   acetyltransferase, putative
Leishmania donovani LdBPK_367340.1   acetyltransferase, putative
Leishmania infantum LinJ.36.7340   acetyltransferase, putative
Leishmania major LmjF.36.6990   acetyltransferase, putative
Leishmania mexicana LmxM.36.6990   acetyltransferase, putative
Schistosoma japonicum Sjp_0216520   Histone acetyltransferase MYST2, putative
Schistosoma mansoni Smp_171700   myst histone acetyltransferase
Trypanosoma brucei gambiense Tbg972.10.10120   acetyltransferase, putative
Trypanosoma brucei Tb927.10.8310   histone acetyltransferase
Trypanosoma congolense TcIL3000_10_7170   acetyltransferase, putative
Trypanosoma cruzi TcCLB.507611.290   acetyltransferase, putative
Trypanosoma cruzi TcCLB.507723.110   acetyltransferase, putative

Essentiality

Smp_171700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.8310 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.8310 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.8310 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.8310 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_171700 (Schistosoma mansoni), myst histone acetyltransferase
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