Detailed view for Smp_072140

Basic information

TDR Targets ID: 294133
Schistosoma mansoni, Rho2 GTPase
Source Database / ID:  GeneDB

pI: 6.2535 | Length (AA): 192 | MW (Da): 21830 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005525   GTP binding  
GO:0003924   GTPase activity  
GO:0015031   protein transport  
GO:0007264   small GTPase mediated signal transduction  

Metabolic Pathways

Endocytosis (KEGG)
Wnt signaling pathway (KEGG)
TGF-beta signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 189 5zhx (f) 3 190 81.00 0 1 1.65066 0.04
4 188 2fv8 (A) 4 184 81.00 0 1 1.97214 -1.81
5 180 2rgn (F) 5 180 86.00 0 1 1.98197 -1.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128099)

Species Accession Gene Product
Brugia malayi Bm1_27295   RAS-like GTP-binding protein RhoA
Brugia malayi Bm1_32605   RAS-like GTP-binding protein RhoA
Brugia malayi Bm1_27290   RAS-like GTP-binding protein RhoA
Candida albicans CaO19.2843   Ras-like GTP-binding protein
Candida albicans CaO19.10362   Ras-like GTP-binding protein
Caenorhabditis elegans CELE_Y51H4A.3   Protein RHO-1
Dictyostelium discoideum DDB_G0291976   Rho GTPase
Drosophila melanogaster Dmel_CG8416   CG8416 gene product from transcript CG8416-RB
Echinococcus granulosus EgrG_000246600   transforming protein RhoA
Echinococcus granulosus EgrG_000246500   transforming protein RhoA
Entamoeba histolytica EHI_013260   Rho family GTPase
Echinococcus multilocularis EmuJ_000246500   transforming protein RhoA
Echinococcus multilocularis EmuJ_000246600   transforming protein RhoA
Homo sapiens ENSG00000067560   ras homolog family member A
Homo sapiens ENSG00000143878   ras homolog family member B
Homo sapiens ENSG00000155366   ras homolog family member C
Loa Loa (eye worm) LOAG_00098   guanine nucleotide regulatory protein
Loa Loa (eye worm) LOAG_14469   hypothetical protein
Loa Loa (eye worm) LOAG_03538   hypothetical protein
Loa Loa (eye worm) LOAG_03537   guanine nucleotide regulatory protein
Mus musculus ENSMUSG00000007815   ras homolog gene family, member A
Mus musculus ENSMUSG00000054364   ras homolog gene family, member B
Mus musculus ENSMUSG00000002233   ras homolog gene family, member C
Mus musculus ENSMUSG00000036463   RIKEN cDNA 4930544G11 gene
Onchocerca volvulus OVOC10085  
Saccharomyces cerevisiae YPR165W   Rho family GTPase RHO1
Schistosoma japonicum Sjp_0098460   IPR013753,Ras,domain-containing
Schistosoma japonicum Sjp_0102350   Ras-like GTP-binding protein rhoA precursor, putative
Schistosoma japonicum Sjp_0090900   ko:K07857 Ras homolog gene family, member C, putative
Schistosoma mansoni Smp_146600   gtpase_rho
Schistosoma mansoni Smp_072140   Rho2 GTPase
Schmidtea mediterranea mk4.002828.00   Ras-like GTP-binding protein Rho1
Schmidtea mediterranea mk4.001218.06  
Schmidtea mediterranea mk4.018923.00  
Trichomonas vaginalis TVAG_322950   rho3, putative

Essentiality

Smp_072140 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y51H4A.3 Caenorhabditis elegans embryonic arrest wormbase
CELE_Y51H4A.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y51H4A.3 Caenorhabditis elegans larval lethal wormbase
CELE_Y51H4A.3 Caenorhabditis elegans sterile wormbase
YPR165W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ras homolog family member A Compounds References
Homo sapiens ras homolog family member C Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0124 0.5512 1
0.0074 1 1
0.031 0.6788 0.5
0.0307 1 1
0.0246 1 1
0.0074 0.5 0.5
0.0145 1 1
0.0297 0.5 0.5
0.0138 0.3992 0.3739
0.0327 1 1
0.0128 0.5 0.5
0.0134 0.8696 0.8639
0.0112 0.4757 1
0.0138 0.3992 0.3739
0.0122 0.4147 1
0.0138 0.3992 0.3739
0.0112 0.4757 1
0.0107 0.4399 0.4399
0.0252 1 0.5
0.0133 1 1
0.0074 0.57 0.57
0.0316 0.7663 0.7663
0.0201 0.3909 1
0.0255 0.5119 0.5111
0.0202 0.5612 1
0.0183 1 1
0.0145 1 1
0.0297 0.5 0.5
0.0201 0.3909 1
0.0061 1 1
0.0121 0.4564 0.6273
0.0138 0.3992 0.3739
0.0123 0.6806 0.6806
0.0297 0.5 0.5
0.0181 0.4152 1
0.0134 0.8696 0.8639
0.0263 0.5209 0.517
0.014 0.5 0.5
0.0121 0.4564 0.6273
0.0127 1 1
0.0112 0.4757 1
0.0131 0.5 0.5
0.0132 0.3893 1
0.0331 0.8346 0.8346

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_072140 (Schistosoma mansoni), Rho2 GTPase
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