Detailed view for Smp_020090

Basic information

TDR Targets ID: 294240
Schistosoma mansoni, family S54 unassigned peptidase (S54 family)
Source Database / ID:  GeneDB

pI: 7.1783 | Length (AA): 401 | MW (Da): 44912 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01694   Rhomboid family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0005509   calcium ion binding  
GO:0004252   serine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 80 1top (A) 3 86 22.00 0.0007 0.99 0.59112 -1.99
8 78 1rro (A) 31 108 34.00 0 1 0.654357 -1.55
18 78 4pcw (A) 8 79 34.00 0 1 0.55642 -1.63
23 73 1s6i (A) 28 69 52.00 0.64 0.69 0.504282 -0.08
30 137 3n51 (A) 369 499 29.00 0.5 0.36 0.396427 -0.01
46 79 1m45 (A) 116 149 29.00 0 0.2 0.449088 -0.73
220 277 5dj4 (A) 79 134 41.00 0.23 0.23 0.322738 2.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131421)

Species Accession Gene Product
Arabidopsis thaliana AT4G23070   RHOMBOID-like protein 7
Brugia malayi Bm1_46270   Rhomboid family protein
Brugia malayi Bm1_26370   Rhomboid family protein
Caenorhabditis elegans CELE_C48B4.2   Protein ROM-2
Caenorhabditis elegans CELE_F26F4.3   Protein ROM-1
Drosophila melanogaster Dmel_CG1697   rhomboid-4
Drosophila melanogaster Dmel_CG33166   stem cell tumor
Echinococcus granulosus EgrG_000102400   stem cell tumor
Echinococcus granulosus EgrG_001126200   stem cell tumor
Echinococcus multilocularis EmuJ_001126200   stem cell tumor
Echinococcus multilocularis EmuJ_000102400   stem cell tumor
Homo sapiens ENSG00000141314   rhomboid, veinlet-like 3 (Drosophila)
Loa Loa (eye worm) LOAG_00008   rhomboid family protein
Loa Loa (eye worm) LOAG_09187   hypothetical protein
Loa Loa (eye worm) LOAG_09186   hypothetical protein
Mus musculus ENSMUSG00000017692   rhomboid, veinlet-like 3 (Drosophila)
Schistosoma japonicum Sjp_0213060   Rhomboid-related protein 2, putative
Schistosoma japonicum Sjp_0302750   ko:K02857 rhomboid-related protein 1/2/3, putative
Schistosoma mansoni Smp_020090   family S54 unassigned peptidase (S54 family)
Schistosoma mansoni Smp_155090   hypothetical protein
Schmidtea mediterranea mk4.003091.00   Rhomboid-related protein 1
Schmidtea mediterranea mk4.000455.04  
Schmidtea mediterranea mk4.002235.01   Rhomboid-related protein 1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_020090 (Schistosoma mansoni), family S54 unassigned peptidase (S54 family)
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