pI: 6.9012 |
Length (AA): 547 |
MW (Da): 62507 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 213 | 4u6u (B) | 141 | 339 | 26.00 | 0.78 | 0.81 | 0.571497 | 0.08 |
10 | 541 | 3vyc (A) | 518 | 1056 | 13.00 | 0 | 0.21 | 1.02968 | 0.03 |
21 | 528 | 5hdt (A) | 433 | 927 | 12.00 | 0 | 0.97 | 0.971802 | 0.31 |
148 | 322 | 2d2s (A) | 532 | 684 | 11.00 | 0 | 0.13 | 0.181027 | -0.01 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128891)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G11980 | conserved oligomeric Golgi complex component-related protein |
Brugia malayi | Bm1_08125 | Conserved oligomeric Golgi complex component 8, putative |
Candida albicans | CaO19.36 | similar to S. cerevisiae COG8 (YML071C) intra-Golgi transport complex subunit |
Candida albicans | CaO19.7709 | similar to S. cerevisiae COG8 (YML071C) conserved oligomeric Golgi complex 8 protein |
Caenorhabditis elegans | CELE_R02D3.2 | Protein COGC-8 |
Dictyostelium discoideum | DDB_G0271388 | Dor1-like protein |
Drosophila melanogaster | Dmel_CG6488 | CG6488 gene product from transcript CG6488-RA |
Echinococcus granulosus | EgrG_000485100 | oligomeric Golgi complex subunit 8 |
Echinococcus multilocularis | EmuJ_000485100 | oligomeric Golgi complex subunit 8 |
Homo sapiens | 84342 | component of oligomeric golgi complex 8 |
Leishmania braziliensis | LbrM.28.3110 | oligomeric golgi complex component 8, putative |
Leishmania donovani | LdBPK_283130.1 | oligomeric golgi complex component 8, putative |
Leishmania infantum | LinJ.28.3130 | oligomeric golgi complex component 8, putative |
Leishmania major | LmjF.28.2900 | oligomeric golgi complex component 8, putative |
Leishmania mexicana | LmxM.28.2900 | oligomeric golgi complex component 8, putative |
Loa Loa (eye worm) | LOAG_07009 | hypothetical protein |
Mus musculus | 97484 | component of oligomeric golgi complex 8 |
Neospora caninum | NCLIV_016740 | Conserved oligomeric Golgi complex component 8, related |
Oryza sativa | 4352423 | Os12g0538300 |
Schistosoma japonicum | Sjp_0029240 | Conserved oligomeric Golgi complex component 8, putative |
Schistosoma mansoni | Smp_161130 | hypothetical protein |
Schmidtea mediterranea | mk4.002136.00 | |
Schmidtea mediterranea | mk4.011640.00 | Conserved oligomeric Golgi complex subunit 8 |
Trypanosoma brucei gambiense | Tbg972.11.12520 | oligomeric golgi complex component 8, putative |
Trypanosoma brucei | Tb927.11.11200 | oligomeric golgi complex component 8, putative |
Trypanosoma congolense | TcIL3000.11.11850 | oligomeric golgi complex component 8, putative |
Trypanosoma cruzi | TcCLB.509119.10 | oligomeric golgi complex component 8, putative |
Trypanosoma cruzi | TcCLB.508831.20 | oligomeric golgi complex component 8, putative |
Toxoplasma gondii | TGME49_240540 | hypothetical protein |
Theileria parva | TP04_0354 | hypothetical protein |
Trichomonas vaginalis | TVAG_341180 | Conserved oligomeric golgi complex component, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.2990 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.2990 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.2990 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.2990 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_240540 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.