Detailed view for Smp_172300

Basic information

TDR Targets ID: 294530
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 10.7957 | Length (AA): 128 | MW (Da): 14769 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00829   Ribosomal prokaryotic L21 protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0003723   RNA binding  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
16 121 4wfa (O) 1 101 25.00 0 0.97 1.03832 0.9
20 120 5dm6 (O) 5 98 28.00 0.033 0.16 0.701662 1.67

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127445)

Species Accession Gene Product
Arabidopsis thaliana AT1G35680   50S ribosomal protein L21
Arabidopsis thaliana AT4G30930   50S ribosomal protein L21
Babesia bovis BBOV_III009380   conserved hypothetical protein
Babesia bovis BBOV_I003410   ribosomal protein L21 domain containing protein
Brugia malayi Bm1_46405   50S ribosomal protein L21, mitochondrial precursor
Caenorhabditis elegans CELE_F43C1.6   Protein MRPL-21
Chlamydia trachomatis CT_420   50S ribosomal protein L21
Dictyostelium discoideum DDB_G0288799   ribosomal protein L21, mitochondrial
Drosophila melanogaster Dmel_CG9730   mitochondrial ribosomal protein L21
Escherichia coli b3186   50S ribosomal subunit protein L21
Echinococcus granulosus EgrG_000660200   39S ribosomal protein L21 mitochondrial
Echinococcus multilocularis EmuJ_000660200   39S ribosomal protein L21, mitochondrial
Homo sapiens ENSG00000197345   mitochondrial ribosomal protein L21
Leishmania braziliensis LbrM.14.0760   hypothetical protein, conserved
Leishmania donovani LdBPK_140840.1   ribosomal protein L21, putative
Leishmania infantum LinJ.14.0840   hypothetical protein, conserved
Leishmania major LmjF.14.0780   hypothetical protein, conserved
Leishmania mexicana LmxM.14.0780   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_01899   50S ribosomal protein L21
Mycobacterium leprae ML1467c   PROBABLE 50S RIBOSOMAL PROTEIN L21 RPLU
Mus musculus ENSMUSG00000024829   mitochondrial ribosomal protein L21
Mycobacterium tuberculosis Rv2442c   50S ribosomal protein L21 RplU
Mycobacterium ulcerans MUL_3714   50S ribosomal protein L21
Neospora caninum NCLIV_041080   ribosomal protein L21, putative
Neospora caninum NCLIV_022580   hypothetical protein
Oryza sativa 4339580   Os05g0557800
Oryza sativa 4328932   Os02g0259600
Plasmodium berghei PBANKA_1021300   mitochondrial ribosomal protein L21 precursor, putative
Plasmodium berghei PBANKA_0703200   apicoplast ribosomal protein L21 precursor, putative
Plasmodium falciparum PF3D7_0827500   apicoplast ribosomal protein L21 precursor, putative
Plasmodium falciparum PF3D7_1422100   mitochondrial ribosomal protein L21 precursor, putative
Plasmodium knowlesi PKNH_1335900   ribosomal protein, putative
Plasmodium knowlesi PKNH_1321600   plastid 50S ribosomal protein, putative
Plasmodium vivax PVX_088985   plastid 50S ribosomal protein L21, putative
Plasmodium vivax PVX_085375   hypothetical protein, conserved
Plasmodium yoelii PY04436   ribosomal protein L21, putative
Plasmodium yoelii PY04493   ribosomal protein L21, putative
Schistosoma mansoni Smp_172300   hypothetical protein
Schmidtea mediterranea mk4.007231.00   39S ribosomal protein L21, mitochondrial
Schmidtea mediterranea mk4.019182.00   39S ribosomal protein L21, mitochondrial
Trypanosoma brucei gambiense Tbg972.7.4650   hypothetical protein, conserved
Trypanosoma brucei Tb927.7.4140   mitochondrial ribosomal protein L21
Trypanosoma congolense TcIL3000_0_00020   ribosomal protein L21, putative
Trypanosoma cruzi TcCLB.510989.40   ribosomal protein L21, putative
Trypanosoma cruzi TcCLB.511245.190   ribosomal protein L21, putative
Toxoplasma gondii TGME49_202350   50S ribosomal protein L21, putative
Toxoplasma gondii TGME49_288610   50S ribosomal protein L21, putative
Treponema pallidum TP0745   50S ribosomal protein L21
Theileria parva TP03_0191   50S ribosomal protein L21, putative
Theileria parva TP04_0847   hypothetical protein, conserved
Wolbachia endosymbiont of Brugia malayi Wbm0701   50S ribosomal protein L21

Essentiality

Smp_172300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2485 Mycobacterium tuberculosis essential nmpdr
Tb927.7.4140 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.4140 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.4140 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.4140 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b3186 Escherichia coli essential goodall
CELE_F43C1.6 Caenorhabditis elegans slow growth wormbase
PBANKA_0703200 Plasmodium berghei Essential plasmo
TGME49_288610 Toxoplasma gondii Probably essential sidik
TGME49_202350 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_172300 (Schistosoma mansoni), hypothetical protein
Title for this comment
Comment