Detailed view for Smp_172620

Basic information

TDR Targets ID: 294856
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 6.5067 | Length (AA): 1365 | MW (Da): 156256 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00488   MutS domain V
PF05188   MutS domain II
PF05190   MutS family domain IV
PF05192   MutS domain III
PF10155   Uncharacterized conserved protein (DUF2363)

Gene Ontology

Mouse over links to read term descriptions.
GO:0030014   CCR4-NOT complex  
GO:0030983   mismatched DNA binding  
GO:0005524   ATP binding  
GO:0006298   mismatch repair  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
388 1246 3thx (B) 281 1112 19.00 0 1 0.655304 0.69
583 1112 1ewq (A) 220 726 29.00 0 1 0.611278 0.26
1299 1365 5j2l (B) 5 71 13.00 0.15 0.02 0.290884 -1.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130077)

Species Accession Gene Product
Arabidopsis thaliana AT4G17380   DNA mismatch repair protein MSH4
Brugia malayi Bm1_28135   MutS domain III family protein
Candida albicans CaO19.10111   similar to S. cerevisiae MutS-like gene
Candida albicans CaO19.2579   similar to S. cerevisiae MutS-like gene
Caenorhabditis elegans CELE_ZK1127.11   Protein HIM-14
Dictyostelium discoideum DDB_G0283957   DNA mismatch repair protein
Echinococcus granulosus EgrG_000871800   protein of unknown function DUF2363
Echinococcus granulosus EgrG_000752400   mutS protein 4
Entamoeba histolytica EHI_112060   DNA mismatch repair protein mutS, putative
Echinococcus multilocularis EmuJ_000752400   mutS protein 4
Echinococcus multilocularis EmuJ_000871800   protein of unknown function DUF2363
Homo sapiens ENSG00000057468   mutS homolog 4
Loa Loa (eye worm) LOAG_05459   hypothetical protein
Mus musculus ENSMUSG00000005493   mutS homolog 4 (E. coli)
Oryza sativa 9266513   Os07g0486000
Onchocerca volvulus OVOC1960   MutS protein homolog
Saccharomyces cerevisiae YFL003C   MutS family protein MSH4
Schistosoma japonicum Sjp_0024310   ko:K08740 DNA mismatch repair protein MSH4, putative
Schistosoma japonicum Sjp_0024320   IPR000432,DNA mismatch repair protein MutS, C-terminal,domain-containing
Schistosoma japonicum Sjp_0024300   similar to Uncharacterized protein C2orf29, putative
Schistosoma mansoni Smp_172620   hypothetical protein
Schmidtea mediterranea mk4.013659.02   MutS protein homolog him-14
Schmidtea mediterranea mk4.013659.03   MutS protein homolog him-14
Schmidtea mediterranea mk4.009234.00  
Trichomonas vaginalis TVAG_455180   meiosis-specific crossover protein Msh4 (mutS homolog)

Essentiality

Smp_172620 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZK1127.11 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZK1127.11 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_172620 (Schistosoma mansoni), hypothetical protein
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