Detailed view for Smp_063340

Basic information

TDR Targets ID: 294892
Schistosoma mansoni, phosphoserine phosphatase
Source Database / ID:  GeneDB

pI: 4.6264 | Length (AA): 223 | MW (Da): 24630 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00702   haloacid dehalogenase-like hydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004647   phosphoserine phosphatase activity  
GO:0003824   catalytic activity  
GO:0016791   phosphoric monoester hydrolase activity  
GO:0006564   L-serine biosynthetic process  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 217 1l8l (A) 11 224 42.00 0 1 1.54626 -0.94
8 216 3kd3 (A) 1 215 31.00 0 1 1.42882 -1.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128110)

Species Accession Gene Product
Arabidopsis thaliana AT1G18640   phosphoserine phosphatase
Brugia malayi Bm1_49380   L-3-phosphoserine phosphatase
Candida albicans CaO19.5838   phosphoserine phosphohydrolase
Candida albicans CaO19.13260   phosphoserine phosphohydrolase
Caenorhabditis elegans CELE_Y62E10A.13   Protein Y62E10A.13, isoform D
Dictyostelium discoideum DDB_G0291368   phosphoserine phosphatase
Drosophila melanogaster Dmel_CG3705   astray
Escherichia coli b4388   3-phosphoserine phosphatase
Echinococcus granulosus EgrG_001063400   phosphoserine phosphatase
Echinococcus granulosus EgrG_001062900   phosphoserine phosphatase
Echinococcus multilocularis EmuJ_001063100   phosphoserine phosphatase
Echinococcus multilocularis EmuJ_001063400   phosphoserine phosphatase
Echinococcus multilocularis EmuJ_001062900   phosphoserine phosphatase
Echinococcus multilocularis EmuJ_001063200   phosphoserine phosphatase
Echinococcus multilocularis EmuJ_001063300   phosphoserine phosphatase
Echinococcus multilocularis EmuJ_001063000   phosphoserine phosphatase
Homo sapiens ENSG00000146733   phosphoserine phosphatase
Loa Loa (eye worm) LOAG_00707   L-3-phosphoserine phosphatase
Mycobacterium leprae ML1727c   PROBABLE PHOSPHOSERINE PHOSPHATASE SERB2 (PSP) (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSPASE)
Mus musculus ENSMUSG00000029446   phosphoserine phosphatase
Mycobacterium tuberculosis Rv3042c   Probable phosphoserine phosphatase SerB2 (PSP) (O-phosphoserine phosphohydrolase) (pspase)
Mycobacterium ulcerans MUL_1888   phosphoserine phosphatase SerB2
Neospora caninum NCLIV_005930   phosphoserine phosphatase, putative
Oryza sativa 4352281   Os12g0502400
Oryza sativa 4350964   Os11g0629500
Onchocerca volvulus OVOC793   Phosphoserine phosphatase homolog
Saccharomyces cerevisiae YGR208W   phosphoserine phosphatase
Schistosoma japonicum Sjp_0011450   expressed protein
Schistosoma mansoni Smp_063340   phosphoserine phosphatase
Schmidtea mediterranea mk4.002114.03   Phosphoserine phosphatase
Toxoplasma gondii TGME49_222900   phosphoserine phosphatase

Essentiality

Smp_063340 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3095 Mycobacterium tuberculosis essential nmpdr
b4388 Escherichia coli non-essential goodall
TGME49_222900 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_063340 (Schistosoma mansoni), phosphoserine phosphatase
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