Detailed view for Smp_164120

Basic information

TDR Targets ID: 294936
Schistosoma mansoni, dopey-related
Source Database / ID:  GeneDB

pI: 7.0255 | Length (AA): 778 | MW (Da): 88845 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04118   Dopey, N-terminal

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
348 428 4bja (A) 100 185 32.00 0.69 0.09 0.217413 0.69

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128921)

Species Accession Gene Product
Babesia bovis BBOV_I003740   dopey, N-terminal domain containing protein
Brugia malayi Bm1_04370   Dopey, N-terminal domain containing protein
Brugia malayi Bm1_54675   hypothetical protein
Candida albicans CaO19.10675   similar to Aspergillus nidulans dopA
Candida albicans CaO19.3166   similar to Aspergillus nidulans dopA
Caenorhabditis elegans CELE_Y18D10A.13   Protein PAD-1
Drosophila melanogaster Dmel_CG15099   CG15099 gene product from transcript CG15099-RB
Echinococcus granulosus EgrG_000045200   protein dopey 1
Echinococcus multilocularis EmuJ_000045200   protein dopey 1
Homo sapiens ENSG00000083097   dopey family member 1
Homo sapiens ENSG00000142197   dopey family member 2
Loa Loa (eye worm) LOAG_04088   hypothetical protein
Mus musculus ENSMUSG00000034973   dopey family member 1
Mus musculus ENSMUSG00000022946   dopey family member 2
Neospora caninum NCLIV_051470   dopey, N-terminal domain-containing protein, putative
Saccharomyces cerevisiae YDR141C   Dop1p
Schistosoma japonicum Sjp_0203630   expressed protein
Schistosoma mansoni Smp_164120   dopey-related
Schistosoma mansoni Smp_164130   dopey-related
Schmidtea mediterranea mk4.015431.00  
Schmidtea mediterranea mk4.015679.04   Dopey-related
Schmidtea mediterranea mk4.008868.03   Dopey-related
Schmidtea mediterranea mk4.014427.00  
Schmidtea mediterranea mk4.008868.02   Dopey-related
Schmidtea mediterranea mk4.009193.04   Dopey-related
Schmidtea mediterranea mk4.009193.05   Dopey-related
Toxoplasma gondii TGME49_214230   Dopey, N-terminal domain-containing protein
Theileria parva TP01_0466   hypothetical protein, conserved

Essentiality

Smp_164120 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y18D10A.13 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y18D10A.13 Caenorhabditis elegans slow growth wormbase
CELE_Y18D10A.13 Caenorhabditis elegans sterile wormbase
YDR141C Saccharomyces cerevisiae inviable yeastgenome
TGME49_214230 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_164120 (Schistosoma mansoni), dopey-related
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