Detailed view for Smp_181000

Basic information

TDR Targets ID: 294998
Schistosoma mansoni, OUT-1 peptidase (C88 family)
Source Database / ID:  GeneDB

pI: 5.8235 | Length (AA): 331 | MW (Da): 37370 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02338   OTU-like cysteine protease

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 74 2faz (A) 0 65 19.00 0.78 0.55 0.400553 -0.05
113 286 3by4 (A) 101 257 36.00 0 1 0.91838 -1.02
115 287 4boq (A) 143 306 51.00 0 1 1.19936 -1.53

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129000)

Species Accession Gene Product
Arabidopsis thaliana AT1G50670   OTU-like cysteine protease family protein
Candida albicans CaO19.10450   potential OTU-like cysteine protease, similar to S. cerevisiae YFL044C
Candida albicans CaO19.2933   potential OTU-like cysteine protease, similar to S. cerevisiae YFL044C
Dictyostelium discoideum DDB_G0271346   C2H2-type zinc finger-containing protein
Drosophila melanogaster Dmel_CG4603   CG4603 gene product from transcript CG4603-RC
Echinococcus granulosus EgrG_000825650   zinc finger C2H2 type
Entamoeba histolytica EHI_064430   OTU-like cysteine protease, putative
Echinococcus multilocularis EmuJ_000825650   zinc finger, C2H2 type
Homo sapiens ENSG00000180667   YOD1 deubiquitinase
Leishmania donovani LdBPK_366280.1   OTU-like cysteine protease, putative
Leishmania infantum LinJ.36.6280   hypothetical protein, conserved
Leishmania major LmjF.36.6020   hypothetical protein, conserved
Leishmania mexicana LmxM.36.6020   hypothetical protein, conserved
Mus musculus 226418   YOD1 OTU deubiquitinating enzyme 1 homologue (S. cerevisiae)
Neospora caninum NCLIV_068020   OTU-like cysteine protease domain-containing protein, putative
Oryza sativa 4328405   Os02g0164800
Saccharomyces cerevisiae YFL044C   Otu1p
Schistosoma japonicum Sjp_0046770   ko:K01076 YOD1 OTU deubiquinating enzyme 1 homolog [EC:3.1.2.-], putative
Schistosoma japonicum Sjp_0107010   Ubiquitin thioesterase OTU1, putative
Schistosoma mansoni Smp_181000   OUT-1 peptidase (C88 family)
Schmidtea mediterranea mk4.005295.01   Ubiquitin thioesterase OTU1
Trypanosoma brucei gambiense Tbg972.10.10680   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.8790   OTU-like cysteine protease, putative
Trypanosoma congolense TcIL3000_10_7560   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509791.20   OTU-like cysteine protease, putative
Trypanosoma cruzi TcCLB.508723.59   OTU-like cysteine protease, putative
Toxoplasma gondii TGME49_277990   OTU family cysteine protease
Trichomonas vaginalis TVAG_320430   spac24c9.14 protein, putative

Essentiality

Smp_181000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.8790 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.8790 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.8790 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.8790 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_277990 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_181000 (Schistosoma mansoni), OUT-1 peptidase (C88 family)
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