Detailed view for Smp_026310

Basic information

TDR Targets ID: 295028
Schistosoma mansoni, zinc binding dehydrogenase

Source Database / ID:  GeneDB

pI: 8.9879 | Length (AA): 356 | MW (Da): 39424 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00107   Zinc-binding dehydrogenase
PF08240   Alcohol dehydrogenase GroES-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0008270   zinc ion binding  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  
GO:0055114   oxidation reduction  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 356 4j6f (A) 0 359 23.00 0 1 1.09888 -0.3
23 355 2vcy (A) 44 373 39.00 0 1 1.45179 -0.81
50 124 1f8f (A) 32 96 48.00 0.000076 0.36 0.479474 0.9
140 263 4oki (A) 672 793 27.00 0.12 0.65 0.738115 -1.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127865)

Species Accession Gene Product
Arabidopsis thaliana AT3G45770   putative trans-2-enoyl-CoA reductase
Brugia malayi Bm1_31850   oxidoreductase, zinc-binding dehydrogenase family protein
Candida albicans CaO19.5450   one of two genes similar to C.tropicalis ETR1 (AAL55472) and ETR2 (AAL55471) fungal mitochondrial medium chain 2-enoyl thioester
Candida albicans CaO19.12905   one of two genes similar to C.tropicalis ETR1 (AAL55472) and ETR2 (AAL55471) fungal mitochondrial medium chain 2-enoyl thioester
Caenorhabditis elegans CELE_W09H1.5   Protein MECR-1
Caenorhabditis elegans CELE_Y48A6B.9   Protein Y48A6B.9, isoform B
Dictyostelium discoideum DDB_G0278095   2-enoyl thioester reductase
Drosophila melanogaster Dmel_CG16935   CG16935 gene product from transcript CG16935-RA
Echinococcus granulosus EgrG_000727100   mitochondrial trans 2 enoyl coenzyme A reductase
Echinococcus multilocularis EmuJ_000727100   mitochondrial trans 2 enoyl coenzyme A reductase
Homo sapiens ENSG00000116353   mitochondrial trans-2-enoyl-CoA reductase
Leishmania braziliensis LbrM.04.0330   hypothetical protein, conserved
Leishmania donovani LdBPK_040280.1   Alcohol dehydrogenase GroES-like domain containing protein, putative
Leishmania infantum LinJ.04.0280   hypothetical protein, conserved
Leishmania major LmjF.04.0290   hypothetical protein, conserved
Leishmania mexicana LmxM.04.0290   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_09612   hypothetical protein
Mus musculus ENSMUSG00000028910   mitochondrial trans-2-enoyl-CoA reductase
Mycobacterium ulcerans MUL_2797   quinone reductase, Qor
Oryza sativa 4351241   Os12g0102100
Oryza sativa 9271884   Os11g0166201
Oryza sativa 9272332   Os11g0102500
Saccharomyces cerevisiae YBR026C   Etr1p
Schistosoma japonicum Sjp_0029890   ko:K07512 mitochondrial trans-2-enoyl-CoA reductase, putative
Schistosoma japonicum Sjp_0205300   ko:K07512 mitochondrial trans-2-enoyl-CoA reductase, putative
Schistosoma mansoni Smp_026310   zinc binding dehydrogenase
Schmidtea mediterranea mk4.014202.01   Trans-2-enoyl-CoA reductase, mitochondrial
Schmidtea mediterranea mk4.014927.01   Trans-2-enoyl-CoA reductase, mitochondrial
Trypanosoma brucei gambiense Tbg972.9.3870   oxidoreductase, putative
Trypanosoma brucei Tb927.9.7190   Trans-2-enoyl-ACP reductase 1, putative
Trypanosoma congolense TcIL3000_9_2430   oxidoreductase, putative
Trypanosoma cruzi TcCLB.506627.20   hypothetical protein, conserved

Essentiality

Smp_026310 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.5260 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.5260 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.5260 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.5260 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Smp_026310 (Schistosoma mansoni), zinc binding dehydrogenase
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