Detailed view for Smp_124060

Basic information

TDR Targets ID: 295117
Schistosoma mansoni, venom allergen-like (VAL) 13 protein
Source Database / ID:  GeneDB

pI: 9.9741 | Length (AA): 236 | MW (Da): 27225 | Paralog Number: 5

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00188   Cysteine-rich secretory protein family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005576   extracellular region  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 148 5vhg (A) 6 152 36.00 0 1 1.12914 -0.84
4 148 5vhg (A) 7 152 43.00 0 1 1.17441 -1.06

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127576)

Species Accession Gene Product
Arabidopsis thaliana AT4G33720   putative pathogenesis-related protein
Arabidopsis thaliana AT1G50060   putative pathogenesis-related protein
Babesia bovis BBOV_III003800   SCP-like extracellular protein family protein
Brugia malayi Bm1_51135   SCP-like extracellular protein
Candida albicans CaO19.7218   potential SCP-like extracellular protein similar to S. cerevisiae PRY2 (YKR013W) plant Pathogen Related PR-1 class of proteins
Candida albicans CaO19.6200   similar to C. albicans RBT4p
Candida albicans CaO19.13580   similar to C. albicans RBT4p
Caenorhabditis elegans CELE_C07A4.3   Protein C07A4.3
Caenorhabditis elegans CELE_F57B7.2   Protein F57B7.2, isoform A
Dictyostelium discoideum DDB_G0286055   hypothetical protein
Drosophila melanogaster Dmel_CG42764   CG42764 gene product from transcript CG42764-RB
Drosophila melanogaster Dmel_CG4270   CG4270 gene product from transcript CG4270-RA
Drosophila melanogaster Dmel_CG31482   CG31482 gene product from transcript CG31482-RA
Drosophila melanogaster Dmel_CG16995   CG16995 gene product from transcript CG16995-RA
Echinococcus granulosus EgrG_000745100   venom allergen val protein
Echinococcus granulosus EgrG_000745000   venom allergen val protein
Echinococcus granulosus EgrG_000373100   venom allergen (val) protein
Echinococcus granulosus EgrG_000376100   Golgi associated plant pathogenesis
Echinococcus granulosus EgrG_000376000   Golgi associated plant pathogenesis
Echinococcus granulosus EgrG_000373200   5'partial|venom allergen val protein
Echinococcus multilocularis EmuJ_000373100   Golgi associated plant pathogenesis
Echinococcus multilocularis EmuJ_000376000   Golgi associated plant pathogenesis
Echinococcus multilocularis EmuJ_000745000   venom allergen (val) protein
Echinococcus multilocularis EmuJ_000376100   Golgi associated plant pathogenesis
Echinococcus multilocularis EmuJ_000373200   venom allergen (val) protein
Echinococcus multilocularis EmuJ_000745100   venom allergen (val) protein
Homo sapiens ENSG00000122694   GLI pathogenesis-related 2
Loa Loa (eye worm) LOAG_01011   hypothetical protein
Mus musculus ENSMUSG00000028480   GLI pathogenesis-related 2
Oryza sativa 4335393   Os04g0289600
Oryza sativa 4352877   Os12g0633400
Onchocerca volvulus OVOC12845  
Onchocerca volvulus OVOC12902  
Onchocerca volvulus OVOC6972  
Plasmodium falciparum PF3D7_0705800   cysteine-rich secretory protein, putative
Plasmodium knowlesi PKNH_0104300   cysteine-rich secretory protein, putative
Plasmodium vivax PVX_087830   cysteine-rich secretory protein, putative
Saccharomyces cerevisiae YKR013W   Pry2p
Saccharomyces cerevisiae YJL079C   Pry1p
Schistosoma japonicum Sjp_0000390   IPR001283,Allergen V5/Tpx-1 related,domain-containing
Schistosoma japonicum Sjp_0000400   Golgi-associated plant pathogenesis-related protein 1, putative
Schistosoma japonicum Sjp_0000410   Golgi-associated plant pathogenesis-related protein 1, putative
Schistosoma japonicum Sjp_0110620   expressed protein
Schistosoma japonicum Sjp_0314330   expressed protein
Schistosoma japonicum Sjp_0204830   Golgi-associated plant pathogenesis-related protein 1, putative
Schistosoma mansoni Smp_124070   venom allergen-like (VAL) 16 protein
Schistosoma mansoni Smp_124050.1   venom allergen-like (VAL) 6 protein
Schistosoma mansoni Smp_163400   venom allergen-like (VAL) 17 protein
Schistosoma mansoni Smp_124050.3   venom allergen-like (VAL) 6 protein
Schistosoma mansoni Smp_124060   venom allergen-like (VAL) 13 protein
Schistosoma mansoni Smp_124050.4   venom allergen-like (VAL) 6 protein
Schmidtea mediterranea mk4.017597.01  
Schmidtea mediterranea mk4.010442.01  
Schmidtea mediterranea mk4.014829.00  
Schmidtea mediterranea mk4.002396.04  
Schmidtea mediterranea mk4.001499.02   Golgi-associated plant pathogenesis-related protein 1
Schmidtea mediterranea mk4.000278.05  
Schmidtea mediterranea mk4.026268.03  
Schmidtea mediterranea mk4.000830.09  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_124060 (Schistosoma mansoni), venom allergen-like (VAL) 13 protein
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