Detailed view for Smp_016050

Basic information

TDR Targets ID: 295165
Schistosoma mansoni, fragile X related 2 frx2
Source Database / ID:  GeneDB

pI: 7.2047 | Length (AA): 777 | MW (Da): 86548 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00013   KH domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003723   RNA binding  
GO:0003676   nucleic acid binding  

Metabolic Pathways

RNA transport (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 77 3o8v (A) 3 89 20.00 0.0015 0.17 0.317612 -0.5
4 247 4qw2 (A) 6 198 31.00 0 1 0.397428 0.39
285 483 2qnd (A) 4 142 40.00 0 1 0.290513 0.28
365 452 2ctj (A) 15 92 27.00 0 0.62 0.368656 -0.74
371 414 1we8 (A) 19 61 47.00 0.51 0.89 0.510028 0.78

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129814)

Species Accession Gene Product
Brugia malayi Bm1_31425   KH domain containing protein
Brugia malayi Bm1_07480   KH domain containing protein
Drosophila melanogaster Dmel_CG6203   CG6203 gene product from transcript CG6203-RC
Echinococcus granulosus EgrG_000524600   fragile X mental retardation syndrome
Echinococcus granulosus EgrG_000853200   fragile X mental retardation syndrome
Echinococcus multilocularis EmuJ_000524600   fragile X mental retardation syndrome
Echinococcus multilocularis EmuJ_000853200   fragile X mental retardation syndrome
Homo sapiens ENSG00000102081   fragile X mental retardation 1
Homo sapiens ENSG00000114416   fragile X mental retardation, autosomal homolog 1
Homo sapiens ENSG00000129245   fragile X mental retardation, autosomal homolog 2
Loa Loa (eye worm) LOAG_08400   KH domain-containing protein
Loa Loa (eye worm) LOAG_13294   KH domain-containing protein
Mus musculus ENSMUSG00000027680   fragile X mental retardation gene 1, autosomal homolog
Mus musculus ENSMUSG00000000838   fragile X mental retardation syndrome 1
Mus musculus ENSMUSG00000018765   fragile X mental retardation, autosomal homolog 2
Onchocerca volvulus OVOC2771  
Schistosoma japonicum Sjp_0208680   Fragile X mental retardation protein 1 homolog, putative
Schistosoma japonicum Sjp_0017160   Fragile X mental retardation syndrome-related protein 1, putative
Schistosoma mansoni Smp_099630   fragile X related 1 frx1
Schistosoma mansoni Smp_016050   fragile X related 2 frx2
Schmidtea mediterranea mk4.000209.01  
Schmidtea mediterranea mk4.009851.01  
Schmidtea mediterranea mk4.001479.05  
Schmidtea mediterranea mk4.009851.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_016050 (Schistosoma mansoni), fragile X related 2 frx2
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