Detailed view for Smp_026100

Basic information

TDR Targets ID: 295229
Schistosoma mansoni, 40S ribosomal protein S28
Source Database / ID:  GeneDB

pI: 11.0845 | Length (AA): 68 | MW (Da): 7693 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01200   Ribosomal protein S28e

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005840   ribosome  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 67 4kzy (c) 6 68 83.00 0 1 1.86167 -0.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127046)

Species Accession Gene Product
Arabidopsis thaliana AT3G10090   40S ribosomal protein S28-1
Arabidopsis thaliana AT5G64140   40S ribosomal protein S28-2
Arabidopsis thaliana AT5G03850   40S ribosomal protein S28-1
Babesia bovis BBOV_IV002240   40S ribosomal protein S28
Brugia malayi Bm1_18535   40S ribosomal protein S28
Caenorhabditis elegans CELE_Y41D4B.5   Protein RPS-28
Cryptosporidium parvum cgd2_2870   40S ribosomal protein S28, no good start Met
Dictyostelium discoideum DDB_G0285597   40S ribosomal protein S28
Drosophila melanogaster Dmel_CG2998   Ribosomal protein S28b
Drosophila melanogaster Dmel_CG15527   Ribosomal protein S28a
Echinococcus granulosus EgrG_001150800   40S ribosomal protein S28
Entamoeba histolytica EHI_038860   40S ribosomal protein S28, putative
Entamoeba histolytica EHI_021450   40S ribosomal protein S28, putative
Echinococcus multilocularis EmuJ_001150800   40S ribosomal protein S28
Giardia lamblia GL50803_3570   Ribosomal protein S28
Homo sapiens 6234   ribosomal protein S28
Leishmania braziliensis LbrM.26.1650   40S ribosomal protein S33, putative
Leishmania braziliensis LbrM.26.1660   40S ribosomal protein S33, putative
Leishmania donovani LdBPK_261620.1   40S ribosomal protein S33, putative
Leishmania donovani LdBPK_261610.1   40S ribosomal protein S33, putative
Leishmania infantum LinJ.26.1630   40S ribosomal protein S33, putative
Leishmania infantum LinJ.26.1620   40S ribosomal protein S33, putative
Leishmania infantum LinJ.26.1610   40S ribosomal protein S33, putative
Leishmania major LmjF.26.1630   40S ribosomal protein S33, putative
Leishmania major LmjF.26.1640   40S ribosomal protein S33, putative
Leishmania mexicana LmxM.26.1630   40S ribosomal protein S33, putative
Leishmania mexicana LmxM.26.1640   40S ribosomal protein S33, putative
Loa Loa (eye worm) LOAG_04348   hypothetical protein
Mus musculus ENSMUSG00000067288   ribosomal protein S28
Neospora caninum NCLIV_003680   40S ribosomal protein S28, related
Oryza sativa 4348607   Os10g0411700
Oryza sativa 4331742   Os03g0167100
Plasmodium berghei PBANKA_1325000   40S ribosomal protein S28e, putative
Plasmodium falciparum PF3D7_1461300   40S ribosomal protein S28e, putative
Plasmodium knowlesi PKNH_1220400   40S ribosomal protein S28e, putative
Plasmodium vivax PVX_117390   40S ribosomal protein S28e, putative
Plasmodium yoelii PY04142   Ribosomal protein S28e
Saccharomyces cerevisiae YOR167C   ribosomal 40S subunit protein S28A
Saccharomyces cerevisiae YLR264W   ribosomal 40S subunit protein S28B
Schistosoma japonicum Sjp_0050900   ko:K02979 small subunit ribosomal protein S28e, putative
Schistosoma mansoni Smp_026100   40S ribosomal protein S28
Schmidtea mediterranea mk4.000819.04   40S ribosomal protein S28
Schmidtea mediterranea mk4.020610.00   40S ribosomal protein S28
Trypanosoma brucei gambiense Tbg972.7.110   40S ribosomal protein S33, putative
Trypanosoma brucei gambiense Tbg972.7.120   40S ribosomal protein S33, putative
Trypanosoma brucei Tb927.7.240   40S ribosomal protein S33, putative
Trypanosoma brucei Tb927.7.230   40S ribosomal protein S33, putative
Trypanosoma cruzi TcCLB.511237.60   40S ribosomal protein S33, putative
Trypanosoma cruzi TcCLB.511237.50   40S ribosomal protein S33, putative
Trypanosoma cruzi TcCLB.506413.20   40S ribosomal protein S33, putative
Trypanosoma cruzi TcCLB.506413.30   40S ribosomal protein S33, putative
Toxoplasma gondii TGME49_209290   ribosomal protein RPS28
Theileria parva TP03_0428   40S ribosomal protein S28e, putative
Trichomonas vaginalis TVAG_050990   40S ribosomal protein S28, putative
Trichomonas vaginalis TVAG_443060   ribosomal protein S28, putative
Trichomonas vaginalis TVAG_272940   ribosomal protein S28, putative
Trichomonas vaginalis TVAG_272950   30S ribosomal protein S28e, putative
Trichomonas vaginalis TVAG_327180   ribosomal protein S28, putative
Trichomonas vaginalis TVAG_266850   30S ribosomal protein S28e, putative
Trichomonas vaginalis TVAG_057380   ribosomal protein S28, putative

Essentiality

Smp_026100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.230 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.230 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.230 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.230 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y41D4B.5 Caenorhabditis elegans larval arrest wormbase
CELE_Y41D4B.5 Caenorhabditis elegans slow growth wormbase
CELE_Y41D4B.5 Caenorhabditis elegans sterile wormbase
YOR167C Saccharomyces cerevisiae inviable yeastgenome
TGME49_209290 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_026100 (Schistosoma mansoni), 40S ribosomal protein S28
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