pI: 8.9992 |
Length (AA): 120 |
MW (Da): 13428 |
Paralog Number:
4
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
16 | 67 | 4wa6 (G) | 11 | 88 | 25.00 | 0.16 | 0.05 | 0.695333 | -0.69 |
43 | 79 | 2b0o (E) | 431 | 467 | 41.00 | 0.27 | 0.57 | 0.770333 | -0.07 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128409)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_36985 | hypothetical protein |
Brugia malayi | Bm1_00175 | LITAF-like protein |
Brugia malayi | Bm1_34810 | hypothetical protein |
Caenorhabditis elegans | CELE_F16F9.1 | Protein F16F9.1 |
Caenorhabditis elegans | CELE_Y37D8A.8 | Protein Y37D8A.8 |
Caenorhabditis elegans | CELE_Y87G2A.19 | Protein Y87G2A.19 |
Caenorhabditis elegans | CELE_F36G3.3 | Protein F36G3.3 |
Caenorhabditis elegans | CELE_Y87G2A.18 | Protein Y87G2A.18 |
Drosophila melanogaster | Dmel_CG4250 | CG4250 gene product from transcript CG4250-RB |
Drosophila melanogaster | Dmel_CG13510 | CG13510 gene product from transcript CG13510-RC |
Echinococcus granulosus | EgrG_001077700 | lipopolysaccharide induced transcription factor |
Echinococcus granulosus | EgrG_000464800 | lipopolysaccharide induced tumor necrosis |
Entamoeba histolytica | EHI_174170 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000464400 | lipopolysaccharide induced TNF alpha factor |
Echinococcus multilocularis | EmuJ_000464800 | lipopolysaccharide induced tumor necrosis |
Echinococcus multilocularis | EmuJ_000464300 | lipopolysaccharide induced TNF alpha factor |
Echinococcus multilocularis | EmuJ_000464500 | lipopolysaccharide induced TNF alpha factor |
Echinococcus multilocularis | EmuJ_001077700 | lipopolysaccharide induced transcription factor |
Homo sapiens | ENSG00000189067 | lipopolysaccharide-induced TNF factor |
Homo sapiens | 101929989 | lipopolysaccharide-induced tumor necrosis factor-alpha factor-like |
Loa Loa (eye worm) | LOAG_12629 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00475 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10240 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00476 | hypothetical protein |
Mus musculus | ENSMUSG00000022500 | LPS-induced TN factor |
Mus musculus | 436336 | predicted gene 5767 |
Onchocerca volvulus | OVOC394 |
|
Onchocerca volvulus | OVOC4509 |
|
Onchocerca volvulus | OVOC2418 |
|
Onchocerca volvulus | OVOC395 |
|
Schistosoma japonicum | Sjp_0028230 | Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog, putative |
Schistosoma japonicum | Sjp_0028250 | Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN, putative |
Schistosoma japonicum | Sjp_0012250 | hypothetical protein |
Schistosoma japonicum | Sjp_0095850 | Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog, putative |
Schistosoma japonicum | Sjp_0028240 | Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog, putative |
Schistosoma japonicum | Sjp_0315470 | expressed protein |
Schistosoma japonicum | Sjp_0116140 | expressed protein |
Schistosoma japonicum | Sjp_0307110 | Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog, putative |
Schistosoma mansoni | Smp_060210 | lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha |
Schistosoma mansoni | Smp_060240 | lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha |
Schistosoma mansoni | Smp_060220 | lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha |
Schistosoma mansoni | Smp_014080 | lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha |
Schistosoma mansoni | Smp_025370 | lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha |
Schmidtea mediterranea | mk4.001764.00 | |
Schmidtea mediterranea | mk4.008464.00 | |
Schmidtea mediterranea | mk4.017285.00 | Cell death-inducing p53-target protein 1 |
Schmidtea mediterranea | mk4.026556.00 | |
Schmidtea mediterranea | mk4.003353.02 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.