Detailed view for LmjF.29.1420

Basic information

TDR Targets ID: 29541
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.2077 | Length (AA): 655 | MW (Da): 72706 | Paralog Number: 1

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 14

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07690   Major Facilitator Superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 293 1pw4 (A) 19 318 13.00 0 0.03 0.5 -0.57
88 279 1mgy (A) 42 231 16.00 0.0000097 0.15 0.5 -1.39
35 256 3o7q (A) 46 280 20.00 0 0.29 0.152031 1.82
198 340 1n9w (A) 113 305 29.00 0.93 0.44 0.213521 1.29
617 652 5hmo (A) 805 840 28.00 0.55 0 0.402862 -1.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile metacyclic. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_136124)

Species Accession Gene Product
Arabidopsis thaliana AT3G01930   major facilitator protein
Arabidopsis thaliana AT5G14120   major facilitator protein
Leishmania braziliensis LbrM.29.1600   hypothetical protein, conserved
Leishmania braziliensis LbrM.29.1610   hypothetical protein, conserved
Leishmania donovani LdBPK_291620.1   major facilitator superfamily, putative
Leishmania donovani LdBPK_291630.1   major facilitator superfamily, putative
Leishmania donovani LdBPK_291610.1   major facilitator superfamily, putative
Leishmania infantum LinJ.29.1620   hypothetical protein, conserved
Leishmania infantum LinJ.29.1610   hypothetical protein, conserved
Leishmania infantum LinJ.29.1630   hypothetical protein, conserved
Leishmania major LmjF.29.1420   hypothetical protein, conserved
Leishmania major LmjF.29.1520   hypothetical protein, conserved
Leishmania mexicana LmxM.08_29.1520   hypothetical protein, conserved
Oryza sativa 4335666   Os04g0388700
Oryza sativa 4346138   Os08g0532400
Trypanosoma cruzi TcCLB.509669.160   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506175.100   hypothetical protein, conserved

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LmjF.29.1420 (Leishmania major), hypothetical protein, conserved
Title for this comment
Comment