Detailed view for Smp_004910

Basic information

TDR Targets ID: 295413
Schistosoma mansoni, rab-2414
Source Database / ID:  GeneDB

pI: 7.6002 | Length (AA): 225 | MW (Da): 24767 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family

Gene Ontology

Mouse over links to read term descriptions.
GO:0055037   recycling endosome  
GO:0045335   phagocytic vesicle  
GO:0032456   endocytic recycling  
GO:0006895   Golgi to endosome transport  
GO:0005802   trans-Golgi network  
GO:0090382   GO:phagosome maturation  

GO:0005622   intracellular  
GO:0005525   GTP binding  
GO:0005515   protein binding  
GO:0003924   GTPase activity  
GO:0042742   defense response to bacterium  
GO:0015031   protein transport  
GO:0007264   small GTPase mediated signal transduction  
GO:0007165   signal transduction  
GO:0006913   nucleocytoplasmic transport  
GO:0006886   intracellular protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 180 2bme (A) 6 178 60.00 0 1 1.66039 -2.07
8 174 1z0f (A) 7 173 80.00 0 1 1.80292 -1.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131501)

Species Accession Gene Product
Brugia malayi Bm1_20650   Ras-related protein Rab-14
Caenorhabditis elegans CELE_K09A9.2   Protein RAB-14
Dictyostelium discoideum DDB_G0281337   Rab GTPase
Drosophila melanogaster Dmel_CG4212   CG4212 gene product from transcript CG4212-RA
Echinococcus granulosus EgrG_000449500   RAB14 member RAS oncogene family
Echinococcus multilocularis EmuJ_000449500   RAB14, member RAS oncogene family
Homo sapiens ENSG00000119396   RAB14, member RAS oncogene family
Leishmania braziliensis LbrM.07.0620   ras-related protein rab-14, putative
Leishmania donovani LdBPK_070610.1   ras-related protein rab-14, putative
Leishmania infantum LinJ.07.0610   ras-related protein rab-14, putative
Leishmania major LmjF.07.0560   ras-related protein rab-14, putative
Leishmania mexicana LmxM.07.0560   ras-related protein rab-14, putative
Loa Loa (eye worm) LOAG_09206   RAB14 protein
Mus musculus ENSMUSG00000026878   RAB14, member RAS oncogene family
Schistosoma japonicum Sjp_0005410   ko:K07881 Ras-related protein Rab-14, putative
Schistosoma mansoni Smp_004910   rab-2414
Schmidtea mediterranea mk4.012813.00   Ras-related protein Rab-14
Schmidtea mediterranea mk4.020471.00   RH10422p
Trypanosoma cruzi TcCLB.504741.240   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511621.120   hypothetical protein, conserved
Trichomonas vaginalis TVAG_001600   Rabx22 protein, putative
Trichomonas vaginalis TVAG_028730   Rabx39 protein, putative
Trichomonas vaginalis TVAG_093060   Rabx30 protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_004910 (Schistosoma mansoni), rab-2414
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