Detailed view for Smp_127000.2

Basic information

TDR Targets ID: 295474
Schistosoma mansoni, cationic amino acid transporter
Source Database / ID:  GeneDB

pI: 9.478 | Length (AA): 1456 | MW (Da): 166059 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 14

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07915   Glucosidase II beta subunit-like protein
PF13520   Amino acid permease

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0016020   membrane  
GO:0005515   protein binding  
GO:0055085   transmembrane transport  
GO:0006810   transport  

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 284 4k6j (A) 815 1132 9.00 0 0.01 0.14984 -0.13
431 841 5oqt (A) 23 452 28.00 0 0.85 0.46608 0.11
432 854 3gia (A) 5 434 21.00 0 0.94 0.474922 -0.67
434 807 5j4i (A) 9 396 26.00 0.000000000034 0.91 0.455668 -0.08
962 1069 3aih (A) 110 229 44.00 0.0071 1 0.606376 -0.64
1197 1374 4uos (A) 1 180 10.00 0.0026 0.01 0.258453 -0.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_178371)

Species Accession Gene Product
Echinococcus multilocularis EmuJ_000651100   cationic amino acid transporter
Schistosoma japonicum Sjp_0104020   expressed protein
Schistosoma japonicum Sjp_0029180   ko:K10088 amplified in osteosarcoma, putative
Schistosoma japonicum Sjp_0301780   ko:K03450 L-amino acid transporter, LAT family, putative
Schistosoma mansoni Smp_127000.2   cationic amino acid transporter
Schistosoma mansoni Smp_127000.1   cationic amino acid transporter

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus L-type amino acid transporter 1 512 aa 42.0% 462 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_127000.2 (Schistosoma mansoni), cationic amino acid transporter
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